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565950

Sialyl Lewis x, Sodium Salt

Name: Sialyl Lewis x, Sodium Salt
Brand: MM

Enzymatically prepared tetrasaccharide which acts as a minimal binding ligand for E-selectins.

Synonyme(s) :

Sialyl Lewis x, Sodium Salt, SLe ^x, Neu5Acα2,3Galβ1,4(Fucα1,3)GlcNAc, SLe^x, Neu5Acα2,3Galβ1,4(Fucα1,3)GlcNAc

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A propos de cet article

Formule empirique (notation de Hill) :

C₃₁H₅₁N₂NaO₂₃

Numéro CAS:

98603-84-0

Poids moléculaire :

842.73

UNSPSC Code:

12352201

NACRES:

NA.79

MDL number:

MFCD00270073

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Propriétés

Quality Segment

100

assay

≥95% (TLC)

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze

color

white

solubility

water: 2 mg/mL

shipped in

wet ice

storage temp.

−20°C

SMILES string

N([C@H]1[C@@H](O[C@@](C[C@@H]1O)(O[C@@H]2[C@H]([C@@H](O[C@@H]([C@@H]2O)CO)O[C@@H]([C@H](O[C@@H]3O[C@H]([C@H]([C@H]([C@@H]3O)O)O)C)[C@@H](NC(=O)C)C=O)[C@H](O)CO)O)C(=O)O)[C@H](O)[C@H](O)CO)C(=O)C

InChI

1S/C31H52N2O23/c1-9-18(43)21(46)22(47)28(51-9)53-24(12(5-34)32-10(2)38)25(15(42)7-36)54-29-23(48)27(20(45)16(8-37)52-29)56-31(30(49)50)4-13(40)17(33-11(3)39)26(55-31)19(44)14(41)6-35/h5,9,12-29,35-37,40-48H,4,6-8H2,1-3H3,(H,32,38)(H,33,39)(H,49,50)/t9-,12-,13-,14+,15+,16+,17+,18+,19+,20-,21+,22-,23+,24+,25+,26+,27-,28-,29-,31-/m0/s1

InChI key

LAQPKDLYOBZWBT-NYLDSJSYSA-N

Description

General description

Enzymatically prepared tetrasaccharide which acts as a minimal binding ligand for E-selectins. SLe^x reduces injury following ischemia and reperfusion and immune complex-induced acute lung injury in animal models. In both of these models, SLe^x is presumed to act by blocking E-selectin-mediated neutrophil recruitment to sites of inflammation.

Other Notes

Seekamp, A., et al. 1994. Am. J. Pathol.144, 592.
Mulligan, M.S., et al. 1993. J. Exp. Med.178, 623.
Ichikawa, Y., et al. 1992. J. Am. Chem. Soc. 114, 9283.
Lasky, L.A. 1992. Science 258, 964.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Classe de stockage

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c