5.08017

nor-Binaltorphimine Dihydrochloride

≥98% (HPLC), solid, κ-opioid receptor antagonist, Calbiochem

• Synonyme(s) : nor-Binaltorphimine Dihydrochloride, Norbinaltorphimine, nor-BNI, κ Opioid Receptor Antagonist, nor-Binaltorphimine
• Formule empirique (notation de Hill) : C₄₀H₄₃N₃O₆ · 2HCl
• Numéro CAS: 105618-26-6
• Poids moléculaire : 734.71
• UNSPSC Code: 12352200
• NACRES: NA.77
• MDL number: MFCD00069374
• Assay: ≥98% (HPLC)
• Form: solid
• Storage condition: OK to freeze, protect from light

Propriétés

• Nom du produit: nor-Binaltorphimine Dihydrochloride,
• assay: ≥98% (HPLC)
• Quality Segment: 100
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze, protect from light
• color: white to off-white
• solubility: water: 50 mM
• storage temp.: −20°C
• SMILES string: N21CC3(C4(C(Oc%12c4c(ccc%12O)CC2C%13CC%13)c5[nH]c6c(c5C3)CC7(C98C6Oc%10c9c(ccc%10O)CC(N(C7)CC8)C%11CC%11)O)CC1)O
• InChI: 1S/C40H43N3O6/c44-27-7-5-21-13-25(19-1-2-19)42-11-9-39-29(21)33(27)48-35(39)31-23(15-37(39,46)17-42)24-16-38(47)18-43-12-10-40(38)30-22(14-26(43)20-3-4-20)6-8-28(45)34(30)49-36(40)32(24)41-31/h5-8,19-20,25-26,35-36,41,44-47H,1-4,9-18H2
• InChI key: GYEXSFKLGQBRBJ-UHFFFAOYSA-N

Description

General description

A potent antagonist highly selective for κ opioid receptor with no effect on µ- or &delta- opioid receptors. Widely used in studies related to pain, addition, anxiety, depression, and sleep.

Biochem/physiol Actions

Primary Target
kappa opioid receptor

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Kishioka, S., et al. 2013. Neurosci. Letters.In press.

Valdez, G., et al. 2012. Pharma. Biochem. and Behavior.102, 44.
Takemori AE et al. 1988. J. Pharmacol. Exp. Ther.246, 255.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Informations sur la sécurité

• Classe de stockage: 11 - Combustible Solids
• Que se passe-t-il ?: WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable