422625

KLF5 Inhibitor, CID 5951923

The KLF5 Inhibitor, CID 5951923 controls the biological activity of KLF5.

• Synonyme(s) : KLF5 Inhibitor, CID 5951923, 2-((1,1-Dioxidotetrahydrothiophen-3-yl)(methyl)amino)-2-oxoethyl-(2E)-3-(3-nitrophenyl)prop-2-enoate
• Formule empirique (notation de Hill): C₁₆H₁₈N₂O₇S
• Numéro CAS: 749872-43-3
• Poids moléculaire : 382.39
• Numéro MDL: MFCD04796932
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.28

Propriétés

• Niveau de qualité: 100
• Pureté: ≥99% (HPLC)
• Forme: solid
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze; protect from light
• Couleur: off-white
• Solubilité: DMSO: 50 mg/mL
• Conditions d'expédition: ambient
• Température de stockage: 2-8°C
• InChI: 1S/C16H18N2O7S/c1-17(14-7-8-26(23,24)11-14)15(19)10-25-16(20)6-5-12-3-2-4-13(9-12)18(21)22/h2-6,9,14H,7-8,10-11H2,1H3/b6-5+
• Clé InChI: URVRJYLSUVXWBC-AATRIKPKSA-N

Description

Description générale

A cell-permeable phenylpropenoate compound that inhibits the proliferation of colon cancer cell lines exhibiting high levels of KLF5 (IC₅₀ = 1.6 µM in DLD-1 cells). Downregulates the expression of early growth response protein 1 (EGR1), which modulates KLF5 expression at transcription level. Shown to activate the EGFR/ERK pathway by stimulating phosphorylation of EGFR-Tyr¹⁰⁶⁸ and ERK1/2-Thr²⁰²/Tyr²⁰⁴. Also, up-regulates the phosphorylation of p38 MAPK-Thr¹⁸⁰/Tyr^182.

A cell-permeable phenylpropenoate compound that inhibits the proliferation of colon cancer cell lines exhibiting high levels of KLF5 (IC₅₀ = 1.6 µM in DLD-1 cells). Downregulates the expression of early growth response protein 1 (EGR1), which modulates KLF5 expression at transcription level. Shown to activate the EGFR/ERK pathway by stimulating phosphorylation of EGFR-Tyr¹⁰⁶⁸ and ERK1/2-Thr²⁰²/Tyr²⁰⁴. Also, up-regulates the phosphorylation of p38 MAPK-Thr¹⁸⁰/Tyr¹⁸².

Conditionnement

Packaged under inert gas

Avertissement

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock Solutions are stable for up to 3 months at -20°C.

Autres remarques

Bialkowska, A., et al. 2011. Mol. Cancer Ther.10, 2043.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable