317505

1,2-Dioctanoyl-sn-glycerol

Cell-permeable activator of protein kinase C (PKC).

• Synonyme(s) : 1,2-Dioctanoyl-sn-glycerol, DOG, PKC Activator IV
• Formule empirique (notation de Hill): C₁₉H₃₆O₅
• Numéro CAS: 60514-48-9
• Poids moléculaire : 344.49
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Forme: oil
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze
• Couleur: clear colorless
• Solubilité: chloroform: soluble; ethyl acetate: soluble
• Conditions d'expédition: wet ice
• Température de stockage: −70°C
• InChI: 1S/C19H36O5/c1-3-5-7-9-11-13-18(21)23-16-17(15-20)24-19(22)14-12-10-8-6-4-2/h17,20H,3-16H2,1-2H3/t17-/m0/s1
• Clé InChI: ZQBULZYTDGUSSK-KRWDZBQOSA-N

Description

Description générale

Cell-permeable activator of protein kinase C (PKC). Exhibits lower affinity for PKC_α than for other isozymes. Shown to mimic the effects of tumor-promoting phorbol diesters on mitogenesis and epidermal growth factor binding and action in intact cells.

Cell-permeable activator of protein kinase C; however, it has lower affinity for PKCa than for other isozymes. Shown to mimic the effects of tumor-promoting phorbol diesters on mitogenesis and epidermal growth factor binding and action in intact cells.

Actions biochimiques/physiologiques

Cell permeable: yes

Primary Target
Protein kinase C

Reversible: no

Conditionnement

Packaged under inert gas

Avertissement

Toxicity: Standard Handling (A)

Reconstitution

Unstable in solution; reconstitute just prior to use.

Remarque sur l'analyse

Single spot by TLC

Autres remarques

Ferro, T.J., et al. 1993. Am. J. Physiol. 264, L7.
MacEwan, D.J., et al. 1993. Eur. J. Pharmacol. 246, 9.
Davis, R.J. 1985. J. Biol. Chem.260, 1562.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Code de la classe de stockage: 10 - Combustible liquids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable