124013

Akt Inhibitor VI, Akt-in

The Akt Inhibitor VI, Akt-in controls the biological activity of Akt. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

• Synonyme(s) : Akt Inhibitor VI, Akt-in, TCL1₁₀₋₂₄, H-AVTDHPDRLWAWEKF-OH
• Formule empirique (notation de Hill): C₈₈H₁₂₃N₂₃O₂₃
• Poids moléculaire : 1871.06
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Pureté: ≥95% (HPLC)
• Forme: lyophilized solid
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze; desiccated (hygroscopic)
• Couleur: white
• Solubilité: water: 1 mg/mL
• Conditions d'expédition: ambient
• Température de stockage: 2-8°C

Description

Description générale

A reversible 15-mer peptide derived from proto-oncogene TCL1 (amino acids 10-24) that acts as a specific inhibitor of Akt. Shown to bind to Akt-PH domain (K_d ~18 µM) and interfere with the Akt-phosphoinositide interaction, thus hindering membrane translocation from the cytosol and downstream biological responses.

A reversible 15-mer peptide derived from the amino acids 10-24 of the proto-oncogene TCL1 (TCL_10-24) and acts as a specific inhibitor of Akt. Shown to bind to the Akt-PH domain (K_d ~18 µM) and interfere with the Akt-phosphoinositide interaction. This peptide, when made cell-permeable (Cat. No. 124014), has been shown to hinder Akt membrane translocation from the cytosol and subsequent downstream biological responses.

Actions biochimiques/physiologiques

Cell permeable: no

Kd ~18 µM in binding to Akt-PH domain

Primary Target
Akt

Product does not compete with ATP.

Reversible: yes

Conditionnement

Packaged under inert gas

Avertissement

Toxicity: Carcinogenic / Teratogenic (D)

Séquence

H-Ala-Val-Thr-Asp-His-Pro-Asp-Arg-Leu-Trp-Ala-Trp-Glu-Lys-Phe-OH

Forme physique

Supplied as an acetate salt.

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Autres remarques

Hiromura, M., et al. 2004. J. Biol. Chem.279, 53407.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 2
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable