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Merck
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Principaux documents

07-531

Sigma-Aldrich

Anti-PIR121-1/Sra-1 Antibody

Upstate®, from rabbit

Synonyme(s) :

Cytoplasmic FMR1-interacting protein 1, Specifically Rac1-associated protein 1, Sra-1, p140sra-1

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About This Item

Code UNSPSC :
12352203
eCl@ss :
32160702
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Niveau de qualité

100

Forme d'anticorps

purified immunoglobulin

Type de produit anticorps

primary antibodies

Clone

polyclonal

Espèces réactives

human, mouse

Fabricant/nom de marque

Upstate®

Technique(s)

immunoprecipitation (IP): suitable
western blot: suitable

Isotype

IgG

Numéro d'accès NCBI

NM_014608

Numéro d'accès UniProt

Q7L576

Conditions d'expédition

dry ice

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... CYFIP1(23191)
mouse ... Cyfip1(20430)

Spécificité

PIR121-1/Sra-1 (aka CYFIP1)

Immunogène

KLH-conjugated, synthetic peptide corresponding to amino acids 872-886 (SQEFQRDKQPNAQPQ-C) of human PIR121-1/Sra-1, with a C-terminal cysteine added for conjugation purposes.

Application

Anti-PIR121-1/Sra-1 Antibody is an antibody against PIR121-1/Sra-1 for use in IP & WB.
Research Category
Apoptosis & Cancer
Research Sub Category
Apoptosis - Additional

Qualité

routinely evaluated by immunoblot on RIPA homogenates from rat brain

Description de la cible

Mr~130kDa

Forme physique

Format: Purified
Protein A purified

Stockage et stabilité

stable 2 years at -20°C from date of shipment

Informations légales

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 1

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S L Blagg et al.
Biochemical Society transactions, 32(Pt 6), 1113-1114 (2004-10-28)
The WASP (Wiskott-Aldrich syndrome protein)/SCAR (suppressor of cAMP receptor) family of adaptor proteins regulate actin polymerization by coupling Rho-family GTPases to the activation of the Arp2/3 complex. SCAR exists within a complex of proteins, including Nap1 (Nck-associated protein 1), PIR121
E Saller et al.
The EMBO journal, 18(16), 4424-4437 (1999-08-17)
p53 mutants in tumours have a reduced affinity for DNA and a reduced ability to induce apoptosis. We describe a mutant with the opposite phenotype, an increased affinity for some p53-binding sites and an increased ability to induce apoptosis. The
The ARP2/3 complex: giving plant cells a leading edge.
Mathur, Jaideep
Bioessays, 27, 377-387 (2005)
Patricia Kunda et al.
Current biology : CB, 13(21), 1867-1875 (2003-11-01)
In animal cells, GTPase signaling pathways are thought to generate cellular protrusions by modulating the activity of downstream actin-regulatory proteins. Although the molecular events linking activation of a GTPase to the formation of an actin-based process with a characteristic morphology
Marco A Salazar et al.
The Journal of biological chemistry, 278(49), 49031-49043 (2003-09-25)
Tuba is a novel scaffold protein that functions to bring together dynamin with actin regulatory proteins. It is concentrated at synapses in brain and binds dynamin selectively through four N-terminal Src homology-3 (SH3) domains. Tuba binds a variety of actin
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