N-905
Nordiazepam solution
1 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®
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About This Item
Produits recommandés
Qualité
certified reference material
Forme
liquid
Conditionnement
ampule of 1 mL
Fabricant/nom de marque
Cerilliant®
drug control
Narcotic Licence Schedule B (Switzerland); psicótropo (Spain); Decreto Lei 15/93: Tabela IV (Portugal)
Concentration
1 mg/mL in methanol
Technique(s)
gas chromatography (GC): suitable
liquid chromatography (LC): suitable
Application(s)
clinical testing
Format
single component solution
Température de stockage
−20°C
Chaîne SMILES
Clc1ccc2NC(=O)CN=C(c3ccccc3)c2c1
InChI
1S/C15H11ClN2O/c16-11-6-7-13-12(8-11)15(17-9-14(19)18-13)10-4-2-1-3-5-10/h1-8H,9H2,(H,18,19)
Clé InChI
AKPLHCDWDRPJGD-UHFFFAOYSA-N
Description générale
Nordiazepam is a benzodiazepine prescribed for treatment of anxiety and panic attacks. This analytical reference standard is suitable for use in LC/MS or GC/MS applications for clinical toxicology, forensic analysis, or urine drug testing applications. Nordiazepam is also a primary urinary metabolite of benzodiazepines diazepam and chlrodiazepoxide.
Application
- Probe Electrospray Ionization Tandem Mass Spectrometry for the Detection and Quantification of Benzodiazepines: This study employs advanced mass spectrometry techniques to enhance the detection and quantification of Nordiazepam and other benzodiazepines, critical for therapeutic drug monitoring in clinical settings. This method ensures high sensitivity and specificity, improving pharmacokinetic studies of benzodiazepine metabolites (Griffeuille et al., 2024).
- Selective Extraction of Diazepam and Its Metabolites from Urine Samples: Details a molecularly imprinted solid-phase extraction method, utilizing analytical grade Nordiazepam for benchmarking, to selectively extract diazepam and its metabolites from urine. This approach is pivotal for forensic and clinical toxicology, providing a reliable method for drug monitoring and abuse detection (Gil Tejedor et al., 2024).
- Hair Analysis in Postmortem Investigations: Discusses the application of hair analysis in forensic science, where Nordiazepam and other drug residues are identified in postmortem samples. This technique is essential for determining drug involvement in unexplained deaths, offering insights into chronic drug use or poisoning (Pelissier-Alicot et al., 2024).
- Diazepam: A comprehensive review of diazepam, detailing its pharmacology, therapeutic use, and metabolism, including Nordiazepam as a significant metabolite. This information is crucial for healthcare professionals to understand the effects, interactions, and potential side effects of this widely used benzodiazepine (2006).
- Trace Analysis of Psychotropic Medications in Environmental Samples: Utilizes ultra-performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) to detect low concentrations of Nordiazepam and other psychotropic medications in environmental samples. This research supports environmental health studies by tracking pharmaceutical pollutants, which can affect water sources and wildlife (Wang et al., 2024).
Produits recommandés
Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
Informations légales
CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Produit(s) apparenté(s)
Réf. du produit
Description
Tarif
Mention d'avertissement
Danger
Mentions de danger
Conseils de prudence
Classification des risques
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
Organes cibles
Eyes,Central nervous system
Code de la classe de stockage
3 - Flammable liquids
Classe de danger pour l'eau (WGK)
WGK 2
Point d'éclair (°F)
49.5 °F - closed cup
Point d'éclair (°C)
9.7 °C - closed cup
Certificats d'analyse (COA)
Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".
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Les clients ont également consulté
Joris C Verster et al.
Sleep medicine reviews, 17(2), 153-159 (2012-08-14)
The use of benzodiazepine receptor agonists can significantly impair driving performance. The aim of this review was to determine if there is a relation between blood concentrations of these drugs and the degree of driving impairment. A literature search was
Salvatore Millefiori et al.
Journal of molecular modeling, 17(2), 281-287 (2010-05-07)
Vertical ionization energies (VIEs) of medazepam, nordazepam and their molecular subunits have been calculated using the electron propagator method in the P3/CEP-31G* approximation. Vertical electron affinities (VEAs) have been obtained with a ∆SCF procedure at the DFT-B3LYP/6-31+G* level of theory.
Laura Mercolini et al.
Talanta, 80(1), 279-285 (2009-09-29)
Diazepam is frequently used as an adjuvant during antidepressant therapy. Recently, some studies have suggested that the treatment with benzodiazepines could have different efficacy in depressed patients as opposed to non-depressed ones. To clarify the matter, a study is currently
Michael J Lamson et al.
Clinical drug investigation, 31(8), 585-597 (2011-07-05)
Acute repetitive seizures (ARS) are a debilitating part of episodic seizure activity that can sometimes progress to status epilepticus. Currently approved treatment that can be administered by non-medical personnel to patients with ARS is a diazepam rectal gel. While effective
Ali Acikgöz et al.
Toxicology and applied pharmacology, 234(2), 179-191 (2008-11-06)
Drug biotransformation is one of the most important parameters of preclinical screening tests for the registration of new drug candidates. Conventional existing tests rely on nonhuman models which deliver an incomplete metabolic profile of drugs due to the lack of
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