M-120

Morphine-6-β-D-glucuronide-D₃ solution

100 μg/mL in methanol: water (1:1), ampule of 1 mL, certified reference material, Cerilliant^®

• Formule empirique (notation de Hill): C₂₃H₂₄NO₉D₃
• Numéro CAS: 219533-69-4
• Poids moléculaire : 464.48
• Numéro MDL: MFCD08275611
• Code UNSPSC : 41116107
• ID de substance PubChem : 329817861
• Nomenclature NACRES : NA.24

Propriétés

• Qualité: certified reference material
• Forme: liquid
• Caractéristiques: Snap-N-Spike^®/Snap-N-Shoot^®
• Conditionnement: ampule of 1 mL
• Fabricant/nom de marque: Cerilliant^®
• drug control: Narcotic Licence Schedule A (Switzerland); estupefaciente (Spain); Decreto Lei 15/93: Tabela IA (Portugal)
• Concentration: 100 μg/mL in methanol: water (1:1)
• Technique(s): gas chromatography (GC): suitable; liquid chromatography (LC): suitable
• Application(s): forensics and toxicology
• Format: single component solution
• Température de stockage: −20°C
• Chaîne SMILES: [2H]C([2H])([2H])N1CC[C@]23[C@H]4Oc5c(O)ccc(C[C@@H]1[C@@H]2C=C[C@@H]4O[C@@H]6O[C@@H]([C@@H](O)[C@H](O)[C@H]6O)C(O)=O)c35
• InChI: 1S/C23H27NO9/c1-24-7-6-23-10-3-5-13(31-22-17(28)15(26)16(27)19(33-22)21(29)30)20(23)32-18-12(25)4-2-9(14(18)23)8-11(10)24/h2-5,10-11,13,15-17,19-20,22,25-28H,6-8H2,1H3,(H,29,30)/t10-,11+,13-,15-,16-,17+,19-,20-,22+,23-/m0/s1/i1D3
• Clé InChI: GNJCUHZOSOYIEC-YTLCJKNCSA-N

Description

Description générale

Morphine-6ß-D-glucuronide is a primary plasma and urinary metabolite of the opiate analgesic morphine. Sold under trade names including MS Contin^®, Kadian^®, Oramorph^®, and Roxanol for pain relief, morphine is also a commonly abused recreational drug. This stable-labeled internal standard is suitable for quantitation of morphine levels in urine, serum, or plasma by LC/MS or GC/MS for pain prescription monitoring, urine drug testing, clinical toxicology, or forensic analysis.

Application

• Comprehensive analysis of analgesics and metabolites: A sophisticated LC-MS/MS method was developed for the simultaneous quantification of analgesics, including Morphine-6-β-D-glucuronide, and their metabolites in human plasma. This technique is pivotal for pharmacokinetic studies in clinical settings, demonstrating the critical role of high-purity analytical standards in medical research (Jutras et al., 2020).


• Enhanced detection in opioid metabolite research: The study utilized advanced LC-MS/MS techniques to assess the presence of opiates and their metabolites, such as Morphine-6-β-D-glucuronide, in urine following cold syrup consumption. This research underscores the utility of stable isotope-labeled compounds in enhancing the sensitivity and accuracy of drug testing protocols (Yen et al., 2020).


• Capillary electrophoresis-mass spectrometry applications: Capillary electrophoresis-mass spectrometry was employed to determine morphine and its isobaric glucuronide metabolites, illustrating a vital analytical approach for precise measurements in biochemical assays, especially in studying complex drug metabolism pathways (Isbell et al., 2015).

Informations légales

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany

Kadian is a registered trademark of Actavis Elizabeth LLC

MS Contin is a registered trademark of Purdue Frederick Company

Oramorph is a registered trademark of AAIPharma, Inc.

Snap-N-Shoot is a registered trademark of Cerilliant Corporation

Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Pictogrammes: GHS02,GHS06,GHS08
• Mention d'avertissement: Danger
• Mentions de danger: H226,H301 + H311 + H331,H370
• Conseils de prudence: P210 - P280 - P301 + P310 + P330 - P302 + P352 + P312 - P304 + P340 + P311
• Classification des risques: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 3 - STOT SE 1
• Organes cibles: Eyes
• Code de la classe de stockage: 3 - Flammable liquids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): 75.2 °F - closed cup
• Point d'éclair (°C): 24 °C - closed cup