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Merck
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918636

Sigma-Aldrich

Low endotoxin GelMA solution

gel strength 300 (bloom), degree of substitution 80%, 0.2 μm, sterile-filtered, GelMA Type B

Synonyme(s) :

GelMA, Gelatin methacrylamide, Gelatin methacrylate, Gelatin methacryloyl

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About This Item

Code UNSPSC :
12352202
Nomenclature NACRES :
NA.23

Niveau de qualité

100

Stérilité

sterile-filtered

Forme

viscous liquid

Concentration

20 wt. % in DPBS (buffer)

Impuretés

≤5 CFU/g Bioburden (Fungal)
≤5 CFU/g Bioburden(Aerobic)
<25 EU/mL Endotoxin

Couleur

colorless to pale yellow

Taille des particules

0.2 μm

pH

6.5-7.5

Température de stockage

−20°C

Application

Low endotoxin GelMA solution is a 20% low endotoxin gelatin methacrylate (GelMA) solution in DPBS buffer. It is sterile filtrated through 0.2 μm sterile filter, and ready to be used in biomedical applications.
GelMA can be used to form hydrogels for tissue engineering and 3D bioprinting. Gelatin methacryloyl (GelMA) is a polymerizable hydrogel material derived from natural extracellular matrix (ECM) components. Due to its low cost, abundance, and retention of natural cell binding motifs, gelatin has become a highly sought material for tissue engineering applications. The addition of photocrosslinkable methacrylamide functional groups in GelMA allows the synthesis of biocompatible, biodegradable, and non-immunogenic hydrogels that are stable in biologically relevant conditions and promote cell adhesion, spreading, and proliferation.

Conditionnement

10 mL in glass bottle

Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 3

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Preparation and characterization of gelatin-poly(methacrylic acid) interpenetrating polymeric network hydrogels as a pH-sensitive delivery system for glipizide.
Gupta V N, et al.
Indian Journal of Pharmaceutical Sciences, 69(1), 64-68 (2007)
Xin Zhao et al.
Advanced healthcare materials, 5(1), 108-118 (2015-04-17)
Natural hydrogels are promising scaffolds to engineer epidermis. Currently, natural hydrogels used to support epidermal regeneration are mainly collagen- or gelatin-based, which mimic the natural dermal extracellular matrix but often suffer from insufficient and uncontrollable mechanical and degradation properties. In
Kristel W M Boere et al.
Acta biomaterialia, 10(6), 2602-2611 (2014-03-05)
Hydrogels can provide a suitable environment for tissue formation by embedded cells, which makes them suitable for applications in regenerative medicine. However, hydrogels possess only limited mechanical strength, and must therefore be reinforced for applications in load-bearing conditions. In most
Jason W Nichol et al.
Biomaterials, 31(21), 5536-5544 (2010-04-27)
The cellular microenvironment plays an integral role in improving the function of microengineered tissues. Control of the microarchitecture in engineered tissues can be achieved through photopatterning of cell-laden hydrogels. However, despite high pattern fidelity of photopolymerizable hydrogels, many such materials
Anh H Nguyen et al.
Acta biomaterialia, 13, 101-110 (2014-12-03)
Gelatin has been commonly used as a delivery vehicle for various biomolecules for tissue engineering and regenerative medicine applications due to its simple fabrication methods, inherent electrostatic binding properties, and proteolytic degradability. Compared to traditional chemical cross-linking methods, such as
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