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901841

Sigma-Aldrich

N-Hydroxysuccinimide ester-poly(ethylene glycol)-b-poly(ε-caprolactone)

PEG average Mn 5,000, PCL average Mn 5,000

Synonyme(s) :

NHS ester PEG-PCL diblock copolymer, NHS ester-PEG-PCL, PEG-b-PCL, PEG-PCL

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About This Item

Formule linéaire :
C10H14NO5S[C2H4O]n[C6H10O2]mH
Code UNSPSC :
12352005
Nomenclature NACRES :
NA.23

Forme

powder or solid

Poids mol.

PCL average Mn 5,000
PEG average Mn 5,000

Couleur

white to off-white

PDI

≤1.3 (by GPC)

Température de stockage

−20°C

Application

N-Hydroxysuccinimide ester-poly(ethylene glycol)-b-poly(ε-caprolactone) is a functionalized, amphiphilic, diblock copolymer composed of a hydrophilic PEG block and a hydrophobic PCL block. These biodegradable, biocompatible polymers can self-assemble to form nanoparticles, such as micelles and polymersomes, in both aqueous and non-aqueous media. Due to these properties, these polymers are widely used in polymeric nanoparticle formulation to achieve controlled and targeted delivery of therapeutic agents (e.g. APIs, genetic material, peptides, vaccines, and antibiotics). Additionally, well-defined nanoparticles with tunable size and properties can be prepared by altering the molecular weight ratios between hydrophilic and hydrophobic blocks, as well as by controlling formulation parameters. The NHS ester functional group on the PEG chain enables rapid and facile surface functionalization, allowing for these materials to be used in applications such as targeted drug delivery.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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Folate-functionalized polymeric micelles for tumor targeted delivery of a potent multidrug-resistance modulator FG020326.
Yang, et al.
Journal of Biomedical Materials Research Part A, 86(1), 48-60 (2008)
Cem Varan et al.
Beilstein journal of nanotechnology, 8, 1446-1456 (2017-09-14)
Background: Brain tumors are the most common tumors among adolescents. Although some chemotherapeutics are known to be effective against brain tumors based on cell culture studies, the same effect is not observed in clinical trials. For this reason, the development

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