389145

(2-Hydroxypropyl)-β-cyclodextrine

average M_w ~1,540

• Synonyme(s) : (2-Hydroxypropyl)-beta-cyclodextrin
• Numéro CAS: 128446-35-5
• Numéro CE : 420-920-1
• Code UNSPSC : 12352201
• ID de substance PubChem : 24864264
• Nomenclature NACRES : NA.22

Propriétés

• Forme: powder
• Activité optique: [α]23/D +125°, c = 1 in H₂O
• Poids mol.: average M_w ~1,540
• Ampleur du marquage: 1.0 molar substitution dextrin
• Chaîne SMILES: CC(O)COCC1OC2OC3C(COCC(C)O)OC(OC4C(COCC(C)O)OC(OC5C(COCC(C)O)OC(OC6C(COCC(C)O)OC(OC7C(COCC(C)O)OC(OC8C(COCC(C)O)OC(OC1C(OCC(C)O)C2OCC(C)O)C(OCC(C)O)C8OCC(C)O)C(OCC(C)O)C7OCC(C)O)C(OCC(C)O)C6OCC(C)O)C(OCC(C)O)C5OCC(C)O)C(OCC(C)O)C4OCC(C)O)C(OCC(C)O)C3OCC(C)O
• InChI: 1S/C63H112O42/c1-22(64)8-85-15-29-50-36(71)43(78)57(92-29)100-51-30(16-86-9-23(2)65)94-59(45(80)38(51)73)102-53-32(18-88-11-25(4)67)96-61(47(82)40(53)75)104-55-34(20-90-13-27(6)69)98-63(49(84)42(55)77)105-56-35(21-91-14-28(7)70)97-62(48(83)41(56)76)103-54-33(19-89-12-26(5)68)95-60(46(81)39(54)74)101-52-31(17-87-10-24(3)66)93-58(99-50)44(79)37(52)72/h22-84H,8-21H2,1-7H3/t22?,23?,24?,25?,26?,27?,28?,29-,30-,31?,32?,33?,34?,35?,36?,37-,38?,39-,40+,41+,42+,43?,44+,45?,46+,47+,48+,49+,50+,51+,52-,53-,54-,55-,56-,57+,58-,59+,60-,61-,62-,63-/m1/s1
• Clé InChI: ODLHGICHYURWBS-RYJYQAAZSA-N

Description

Description générale

2-Hydroxypropyl-β-cyclodextrin is a cyclic oligosaccharide and used as a pharmaceutical excipient to improve the stability and bioavailability of drugs.

(2-Hydroxypropyl)-β-cyclodextrin, a hydroxyalkyl derivative, is mainly used as a formulation vehicle to increase the dissolution of drugs in water for the successful delivery of medicinal agents to biological systems. It is commonly utilized as a substitute for α-, β- and γ-cyclodextrins.

Application

(2-Hydroxypropyl)-β-cyclodextrin may be used:

• As an analytical standard for the determination of the analyte in pharmaceutical formulations as well as nanoparticle formulations by thin layer chromatography (TLC) and high performance liquid chromatography (HPLC), respectively.
• To study the host-guest interaction with organic low molecular mass compounds prior to their quantification using reversed phase HPLC technique.
• As a mobile phase additive for the effective separation of β-carbolines by HPLC.
• In cyclodextrin-modified micellar electrokinetic chromatography (CD-modified MEKC) for the determination of sertraline hydrochloride and the synthesis-related products.
• As a chiral selector to resolve pantothenic acid by capillary electrophoresis.

La solubilité des médicaments lipophiles augmente de manière linéaire avec la concentration en hydroxypropyl-β-cyclodextrine (HPCD) en solution aqueuse du fait de la formation d′un complexe HBC-médicament. Ce complexe de type invité-hôte, où le médicament se loge dans la cavité non polaire de la HPCD, améliore la solubilité du médicament. Les solutions peuvent être lyophilisées pour obtenir des poudres facilement solubles. Non toxique chez le lapin et la souris.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)