SML0583

Ferrostatin-1

≥95% (HPLC), powder, non-apoptotic cell death inhibitor

• Synonym(s): 3-Amino-4-cyclohexylaminobenzoic acid ethyl ester;
• Empirical Formula (Hill Notation): C₁₅H₂₂N₂O₂
• CAS Number: 347174-05-4
• Molecular Weight: 262.35
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• Product Name: Ferrostatin-1, ≥95% (HPLC)
• Quality Level: 100
• Assay: ≥95% (HPLC)
• form: powder
• color: , faint purple to brown
• solubility: DMSO: 10 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: N(C2CCCCC2)c1c(cc(cc1)C(=O)OCC)N
• InChI: 1S/C15H22N2O2/c1-2-19-15(18)11-8-9-14(13(16)10-11)17-12-6-4-3-5-7-12/h8-10,12,17H,2-7,16H2,1H3
• InChI key: UJHBVMHOBZBWMX-UHFFFAOYSA-N

Description

Application

Ferrostatin-1 has been used to determine its inhibitory effect on the cell death profiles.

Biochem/physiol Actions

Ferrostatin-1 is a potent inhibitor of non-apoptotic cell death induced by erastin call ferroptosis. Ferrostatin-1 prevents ferroptopic cell death in cancer cells and glutamate-induced toxicity in organotypic rat brain slices. It appears that Ferrostatin-1 controls lipid soluble ROS.

Ferrostatin-1 is an active radical-trapping antioxidant that traps peroxyl radicals, and thus serves as a potential inhibitor of ferroptosis. Ferroptosis is considered as regulated necrosis, which differs from apoptosis and autophagy. Ferrostatin-1 is known to show protective effects against Huntington′s disease and also prevents neurotoxicity induced by glutamate in cellular models.

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H315,H319,H335
• Precautionary Statements: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Target Organs: Respiratory system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable