C5424
Conduritol B epoxide
powder, ≥95% (TLC)
Synonym(s):
1,2-Anhydro-myo-inositol
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About This Item
CAS Number:
MDL number:
UNSPSC Code:
12352119
PubChem Substance ID:
NACRES:
NA.32
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Product Name
Conduritol B epoxide,
biological source
synthetic (organic)
Quality Level
Assay
≥95% (TLC)
form
powder
solubility
water: 20 mg/mL, clear, colorless to faintly yellow
storage temp.
2-8°C
SMILES string
OC1C(O)C(O)C2OC2C1O
InChI
1S/C6H10O5/c7-1-2(8)4(10)6-5(11-6)3(1)9/h1-10H
InChI key
ZHMWOVGZCINIHW-UHFFFAOYSA-N
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Related Categories
General description
Conduritol B epoxide (CBE) is a mix of 1-L-1,2-anhydro-myo-inositol and 1-D-1,2-anhydro-myo-inositol.
Application
Conduritol B epoxide has been used as an inhibitor of GBA1 to discriminate between acid β-glucosidase (GBA1) and non-lysosomal β-glucosidase (GBA2) activity in β-glucosidase activity assay. It has also been used as a selective glucocerebrosidase (GCase) inhibitor.
Biochem/physiol Actions
Conduritol B epoxide (CBE) is capable of inactivating sucrase-isomaltase irreversibly. It can be used to produce cell and animal models to study on Gaucher disease (GD) and Parkinson′s disease (PD).
β-Glucosidase inhibitor
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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In vivo inactivation of glycosidases by conduritol B epoxide and cyclophellitol as revealed by activity-based protein profiling
Kuo CL, et al.
FEBS Journal, 286(3), 584-600 (2019)
Neuronal Soma-Derived Degradative Lysosomes Are Continuously Delivered to Distal Axons to Maintain Local Degradation Capacity
Farfel-BT, et al.
Cell Reports, 28(1), 51-64 (2019)
Stereospecific ring opening of conduritol-B-epoxide by an active site aspartate residue of sucrase-isomaltase
Braun H, et al.
Biochimica et Biophysica Acta, 483(1), 135-140 (1977)
S C Datta et al.
Biochemical and biophysical research communications, 152(1), 155-160 (1988-04-15)
A model of the human genetic disorder, Gaucher disease, can be rapidly generated in mice by the injection of emulsified glucosylceramide and an inhibitor of the lipid's hydrolase, conduritol B epoxide. The liver grows rapidly as it absorbs the load
Identification of a feedback loop involving beta-glucosidase 2 and its product sphingosine sheds light on the molecular mechanisms in Gaucher disease
Schonauer S, et al.
Test, 292(15), 6177-6189 (2017)
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