- Branched/linear selectivity in palladium-catalyzed allyl-allyl cross-couplings: The role of ligands.
Branched/linear selectivity in palladium-catalyzed allyl-allyl cross-couplings: The role of ligands.
Tetrahedron (2015-08-19)
Michael J Ardolino, James P Morken
PMID26279591
ABSTRACT
While Pd-catalyzed allyl-allyl cross-couplings in the presence of small-bite-angle bidentate ligands reliably furnish the branched regioisomer with high levels of selectivity, cross-couplings in the presence of large-bite-angle bidentate ligands give varying, often unpredictable, levels of selectivity. In a combined computational and experimental study, we probe the underlying features that govern the regioselectivity in these metal-catalyzed cross-couplings.
MATERIALS
Product Number
Brand
Product Description
Sigma-Aldrich
Triphenylphosphine, polymer-bound, 100-200 mesh, extent of labeling: ~3.2 mmol/g loading
Sigma-Aldrich
Triphenylphosphine, polymer-bound, 100-200 mesh, extent of labeling: ~3 mmol/g triphenylphosphine loading
Sigma-Aldrich
Triphenylphosphine, polymer-bound, 100-200 mesh, extent of labeling: ~1-1.5 mmol/g Capacity (Phosphor)
Sigma-Aldrich
Triphenylphosphine, polymer-bound, 100-200 mesh, extent of labeling: ~3.0 mmol/g loading, 2 % cross-linked with divinylbenzene