Skip to Content
Merck
  • Monitoring of chemical elements and oxidative damage in patients affected by Alzheimer's disease.

Monitoring of chemical elements and oxidative damage in patients affected by Alzheimer's disease.

Annali dell'Istituto superiore di sanita (2005-10-26)
Beatrice Bocca, Giovanni Forte, Francesco Petrucci, Anna Pino, Francesca Marchione, Giuseppe Bomboi, Oreste Senofonte, Franco Giubilei, Alessandro Alimonti
PMID16244393
ABSTRACT

The haematic concentration of 26 metals and the oxidative damage in 60 patients (20 males and 40 females) affected by Alzheimer's disease and 44 healthy individuals (33 males and 11 females) were compared. In patients, the following significant (p < or = 0.05) discrepancies were found: i) increment of Ca, Cd, Hg, Mg, Si and Sn, and decrement of Al, Co, Fe and Zn in serum; ii) higher concentrations of Cu, Li, Mn, Sn and Zr and lower of Fe, Hg, Mo in blood; iii) overproduction of oxidant species (SOS) and decrease of the anti-oxidant capacity (SAC) (p < or = 0.001, for both). Variables that, joined, better discriminated between patients and controls resulted to be Si, SOS, SAC, Co, Ca, Al in serum (94% of cases correctly classified) and Cu, Zr, Mo and Fe in blood (90% of cases properly categorized).

MATERIALS
Product Number
Brand
Product Description
94119
Supelco
Glycine, analytical standard, for nitrogen determination according to Kjeldahl method
93693
Supelco
L-Proline, certified reference material, TraceCERT®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland
697745
Sigma-Aldrich
Cobalt, Carbon coated magnetic, nanopowder, <50 nm particle size (TEM), ≥99%
76526
Supelco
L-Leucine, certified reference material, TraceCERT®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland
76524
Supelco
Glycine, certified reference material, TraceCERT®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland
51572
Supelco
L-Aspartic acid, certified reference material, TraceCERT®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland
PHR1172
Supelco
L-Valine, Pharmaceutical Secondary Standard; Certified Reference Material
653608
Sigma-Aldrich
Aluminum, powder, <5 μm particle size, 99.5% trace metals basis
749060
Sigma-Aldrich
Zinc, sputtering target, diam. × thickness 3.00 in. × 0.125 in., 99.995% trace metals basis
749036
Sigma-Aldrich
Aluminum, sputtering target, diam. × thickness 3.00 in. × 0.125 in., 99.9995% trace metals basis
67226
Supelco
Tin (impurities), manufactured by MBH Analytical Ltd (71X SR0)
66955
Supelco
Copper (impurities), manufactured by MBH Analytical Ltd (39X 17868)
PHR1104
Supelco
L-Aspartic acid, Pharmaceutical Secondary Standard; Certified Reference Material
PHR1006
Supelco
Sorbitol, Pharmaceutical Secondary Standard; Certified Reference Material
PHR1007
Supelco
Mannitol, Pharmaceutical Secondary Standard; Certified Reference Material
PHR1111
Supelco
Glycine, Pharmaceutical Secondary Standard; Certified Reference Material
61506
Supelco
L-Threonine, certified reference material, TraceCERT®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland
91515
Supelco
L-Tyrosine, certified reference material, TraceCERT®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland
50848
Supelco
L-Valine, certified reference material, TraceCERT®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland
49603
Supelco
L-Cystine, certified reference material, TraceCERT®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland
A5502
Sigma-Aldrich
Adonitol, ≥99%
A9256
Sigma-Aldrich
L-Aspartic acid, reagent grade, ≥98% (HPLC)
81709
Sigma-Aldrich
L-Proline, BioUltra, ≥99.5% (NT)
11189
Sigma-Aldrich
L-Aspartic acid, BioUltra, ≥99.5% (T)
93829
Sigma-Aldrich
L-Tyrosine, BioUltra, ≥99.0% (NT)
56250
Sigma-Aldrich
trans-4-Hydroxy-L-proline, BioXtra, ≥99.0% (NT)
50058
Sigma-Aldrich
Glycine, tested according to Ph. Eur.
M0200000
Mannitol, European Pharmacopoeia (EP) Reference Standard
755702
Sigma-Aldrich
Tin, powder, -100 mesh, 99.99% trace metals basis
PHR1097
Supelco
L-Tyrosine, Pharmaceutical Secondary Standard; Certified Reference Material