T0699

Trichloroacetic acid solution

6.1 N

• Synonym(s): TCA
• Linear Formula: Cl₃CCOOH
• CAS Number: 76-03-9
• Molecular Weight: 163.39
• Beilstein: 970119
• MDL number: MFCD00004177
• UNSPSC Code: 12352106
• PubChem Substance ID: 57654645
• NACRES: NA.26

Properties

• form: liquid
• concentration: 6.1 N; ~100 % (w/v)
• SMILES string: OC(=O)C(Cl)(Cl)Cl
• InChI: 1S/C2HCl3O2/c3-2(4,5)1(6)7/h(H,6,7)
• InChI key: YNJBWRMUSHSURL-UHFFFAOYSA-N

Description

General description

Trichloroacetic acid (TCA) is a strong acid. At the pH of drinking water, TCA exists almost in salt form.

Application

Trichloroacetic acid solution has been used:

• in indoleamine 2,3-dioxygenase (IDO) enzyme assay to hydrolyze N-formylkynurenine and produce kynurenine
• in the proliferation of human pulmonary artery smooth muscle cells (HPASMCs)
• to treat ground tissue and precipitate proteins during protein extraction and quantification

Biochem/physiol Actions

Trichloroacetic acid solution is traditionally used to precipitate protein. It can be used to determine protein concentration by quantitative precipitation. Trichloroacetic acid can also be used as a decalcifier and fixative in microscopy.

Trichloroacetic acid (TCA) with no known systemic toxicity, is used as a time-honored agent for superficial peeling. It is a peroxisome proliferator.

Safety Information

• Pictograms: GHS05,GHS07,GHS09
• Signal Word: Danger
• Hazard Statements: H314,H335,H410
• Precautionary Statements: P261 - P271 - P273 - P280 - P303 + P361 + P353 - P305 + P351 + P338
• Hazard Classifications: Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - Skin Corr. 1A - STOT SE 3
• Target Organs: Respiratory system
• Storage Class Code: 8A - Combustible corrosive hazardous materials
• WGK: WGK 2
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable