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T0410

Sigma-Aldrich

Tiapride hydrochloride

Synonym(s):

N-[2-(Diethylamino)ethyl]-5-(methylsulfonyl)-o-anisamide hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C15H24N2O4S · HCl
CAS Number:
51012-32-9
Molecular Weight:
364.89
EC Number:
256-908-4
MDL number:
MFCD00133861
UNSPSC Code:
12352200
PubChem Substance ID:
24278720

storage temp.

2-8°C

SMILES string

Cl.CCN(CC)CCNC(=O)c1cc(ccc1OC)S(C)(=O)=O

InChI

1S/C15H24N2O4S.ClH/c1-5-17(6-2)10-9-16-15(18)13-11-12(22(4,19)20)7-8-14(13)21-3;/h7-8,11H,5-6,9-10H2,1-4H3,(H,16,18);1H

InChI key

OTFDPNXIVHBTKW-UHFFFAOYSA-N

Gene Information

human ... DRD2(1813) , DRD3(1814)

Application

Tiapride and inhibitor of nitric oxide synthase were coadministered to mice to study the effect of dopamine D2 transmission in catalepsy.

Biochem/physiol Actions

Tiapride, an atypical neuroleptic agent, antagonizes D2 and D3 dopamine receptors. It exhibits anti-dyskinetic and anxiolytic activities. It is effective in the management of alcohol withdrawal and treatment of tic disease in children.

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
080H0354
080H0354V

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C Eggers et al.
European archives of psychiatry and neurological sciences, 237(4), 223-229 (1988-01-01)
Tiapride, a substituted benzamide derivative, possesses good clinical antidyskinetic properties due to its DA2-blocking activities. It has been shown to be clinically effective in the treatment of tic disease in children. In order to study tiapride's antidyskinetic properties in the
C Cohen et al.
The Journal of pharmacology and experimental therapeutics, 283(2), 566-573 (1997-11-14)
The ability of tiapride, a selective D2/D3 dopamine receptor antagonist, to exert discriminative stimulus control of responding was investigated by training rats to discriminate this drug (30 mg/kg) from saline in a two-lever, food-reinforcement procedure. Acquisition of tiapride discrimination required
Maria Cavas et al.
Progress in neuro-psychopharmacology & biological psychiatry, 26(1), 69-73 (2002-02-21)
This study was designed to determine the possible potentiation of catalepsy behavior after coadministration of N(G)-nitro-L-arginine (L-NOARG), an inhibitor of nitric oxide synthase (NOS), and tiapride, a specific antagonist for D2 receptors, in male mice. Catalepsy was measured by the
M S Lidow et al.
The Journal of pharmacology and experimental therapeutics, 283(2), 939-946 (1997-11-14)
The RNase Protection Assay was used to examine the regulation of D2 and D4 dopamine receptor mRNAs in the cerebral cortex and neostriatum of nonhuman primates after chronic treatment with a wide spectrum of antipsychotic medications (chlorpromazine, clozapine, haloperidol, molindone
Transcortical motor aphasia and unilateral parkinsonism in a case of hyperostosis frontalis.
Stefan Brodoehl et al.
Neurology, 80(16), 1536-1537 (2013-04-17)
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