SRP6538

Lipocalin-2/LCN2 from rat

recombinant, expressed in HEK 293 cells, ≥90% (SDS-PAGE)

• Synonym(s): 24p3, MSFI, NGAL, Neutrophil Gelatinase-associated Lipocalin, Oncogene 24p3, Siderocalin
• UNSPSC Code: 12352200
• NACRES: NA.32

Properties

• biological source: rat
• recombinant: expressed in HEK 293 cells
• Assay: ≥90% (SDS-PAGE)
• form: liquid
• mol wt: monomer ~250 kDa (Rat lipocalin-2 aa 1-198 is fused at the C-terminus to a FLAG0174-tag.)
• packaging: pkg of 10 and 50 μg
• impurities: <0.1 EU/μg endotoxin (LAL test)
• UniProt accession no.: P30152
• shipped in: wet ice
• storage temp.: −20°C
• Gene Information: rat ... LCN2(170496)

Description

General description

Lipocalin-2 (LCN2), also known as oncogene 24p3 or neutrophil gelatinase-associated lipocalin (NGAL), MSFI, The binding of lipocalin-2 to bacterial siderophores is important in the innate immune response to bacterial infection. Upon encountering invading bacteria the toll-like receptors on immune cells stimulate the synthesis and secretion of lipocalin-2. Secreted lipocalin-2 then limits bacterial growth by sequestering iron-containing siderophores. Lipocalin-2 also functions as a growth factor. LCN2 is strongly upregulated during inflammation and is upregulated by interleukin 1 (but not TNF α) in humans. There are indications that some forms of acne could be caused due to the gene not being transcribed, and that Isotretinoin corrects this. NFAT3 (NFATc4) NFAT by blocking the expression of LCN2 inhibits breast carcinoma cell motility. Recent studies have revealed that NGAL plays an important role in the physiopathology of chronic myeloid leukaemia (CML) mediated by BCR-ABL.

Physical form

0.2 μm-filtered solution in PBS.

Safety Information

• Storage Class Code: 13 - Non Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable