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Key Documents

SRP4838

Sigma-Aldrich

PTEN human

recombinant, expressed in E. coli

Synonym(s):

5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN, Mutated in multiple advanced cancers 1, PTEN, Phosphatase and tensin homolog, Phosphatidylinositol-3

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About This Item

MDL number:
MFCD03458266
UNSPSC Code:
12352202
NACRES:
NA.32

biological source

human

recombinant

expressed in E. coli

Assay

≥90%

form

liquid

mol wt

~86.0 kDa

packaging

pkg of 5 μg

storage condition

avoid repeated freeze/thaw cycles

impurities

<0.1 EU/μg

NCBI accession no.

P60484

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... PTEN(5728)

Biochem/physiol Actions

PTEN, a tumor suppressor, has been implicated in a large number of human tumors and is conserved from humans to worms. Characterization of PTEN protein showed that it is a phosphatase that acts on proteins and on 3-phosphorylated phosphoinositides, and can therefore modulate signal-transduction pathways that involve lipid second messengers. Recent results indicate that at least part of its role is to regulate the activity of the serine/threonine kinase AKT/PKB, and thus influence cell survival signaling. Recombinant PTEN is purified by proprietary chromatographic techniques.

Physical form

Sterile filtered liquid at 100 μg/ml.

Reconstitution

Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.

Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Tasneem Bawa-Khalfe et al.
Oncotarget, 8(11), 17651-17664 (2016-11-17)
SUMO protease SENP1 is elevated in multiple carcinomas including prostate cancer (PCa). SENP1 exhibits carcinogenic properties; it promotes androgen receptor-dependent and -independent cell proliferation, stabilizes HIF1α, increases VEGF, and supports angiogenesis. However, mice expressing an androgen-responsive promoter driven SENP1-transgene (SENP1-Tg)
Sarah A Altınoğlu et al.
Biomaterials science, 4(12), 1773-1780 (2016-10-18)
The phosphatase and tensin homolog deleted on chromosome 10 (PTEN) is a tumor suppressor, mutated or inactive in a large percentage of human cancers. Restoring PTEN activity in cancer cells through gene therapy has shown to inhibit cell growth and
Bjoern C Froehlich et al.
Proteomics. Clinical applications, 14(5), e2000034-e2000034 (2020-07-10)
Immuno-MALDI (iMALDI) combines immuno-enrichment of biomarkers with MALDI-MS for fast, precise, and specific quantitation, making it a valuable tool for developing clinical assays. iMALDI assays are optimized for the PI3-kinase signaling pathway members phosphatase and tensin homolog (PTEN) and PI3-kinase
Mohammad Imran Khan et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 33(3), 3198-3211 (2018-11-01)
Growth factor receptor-binding protein 10 (GRB10) is a well-known adaptor protein and a recently identified substrate of the mammalian target of rapamycin (mTOR). Depletion of GRB10 increases insulin sensitivity and overexpression suppresses PI3K/Akt signaling. Because the major reason for the
Tuo Yang et al.
Redox biology, 17, 323-337 (2018-05-19)
Brain ischemic preconditioning (IPC) with mild ischemic episodes is well known to protect the brain against subsequent ischemic challenges. However, the underlying mechanisms are poorly understood. Here we demonstrate the critical role of the master redox transcription factor, nuclear factor
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