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SML2790

Sigma-Aldrich

YU254403

≥98% (HPLC)

Synonym(s):

4-{7,9-dichloro-1H,2H,3H,3aH,4H,5H,9bH-cyclopenta[c]quinolin-4-yl}benzoic acid

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About This Item

Empirical Formula (Hill Notation):
C19H17Cl2NO2
CAS Number:
2561494-75-3
Molecular Weight:
362.25
UNSPSC Code:
51111800
NACRES:
NA.77
Pricing and availability is not currently available.

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

O=C(C1=CC=C(C(NC2=CC(Cl)=C3)C4CCCC4C2=C3Cl)C=C1)O

InChI

1S/C19H17Cl2NO2/c20-12-8-15(21)17-13-2-1-3-14(13)18(22-16(17)9-12)10-4-6-11(7-5-10)19(23)24/h4-9,13-14,18,22H,1-3H2,(H,23,24)

InChI key

PHDZTYHPMHMZPG-UHFFFAOYSA-N

Biochem/physiol Actions

YU254403 is a potent inhibitor of phosphatidylserine decarboxylases (PSD) including Plasmodium knowlesi phosphatidylserine decarboxylases (PkPSD). YU254403 potently inhibits growth of pathogenic yeast Candida albicans, and other pathogens including Aspergillus fumigatus and Fusarium solani.
potent inhibitor of phosphatidylserine decarboxylases (PSD)

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Adam Hendricson et al.
The Journal of biological chemistry, 294(32), 12146-12156 (2019-06-23)
Phosphatidylserine decarboxylases (PSDs) catalyze the decarboxylation of phosphatidylserine to generate phosphatidylethanolamine, a critical step in phospholipid metabolism in both prokaryotes and eukaryotes. Most PSDs are membrane-bound, and classical radioisotope-based assays for determining their activity in vitro are not suitable for

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