SML2032
Win6mer trifluoroacetate salt
≥98% (HPLC)
Synonym(s):
Ac-ARTEVY-NH2 trifluouroaceate salt
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About This Item
Empirical Formula (Hill Notation):
C34H54N10O11 · xC2HF3O2
CAS Number:
Molecular Weight:
778.85 (free base basis)
UNSPSC Code:
12352200
NACRES:
NA.77
Assay
≥98% (HPLC)
form
film (Clear)
color
white to off-white
shipped in
wet ice
storage temp.
−20°C
SMILES string
C[C@H](NC(C)=O)C(N[C@H](C(N[C@@](C(N[C@H](C(N[C@H](C(N[C@H](C(N)=O)CC1=CC=C(C=C1)O)=O)C(C)C)=O)CCC(O)=O)=O)([H])[C@H](O)C)=O)CCCNC(N)=N)=O
Biochem/physiol Actions
Win6mer is a potent and specific inhibitor of MLL1 and SETd1A histone H3 lysine 4 (H3K4) methyltransferase complexes that does not inhibit MLL2-4 or SETd1B complexes. Win6mer potently binds to WDR5 in a 310-helical conformation. It does not inhibit isolated SET domain activity.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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Nilda L Alicea-Velázquez et al.
The Journal of biological chemistry, 291(43), 22357-22372 (2016-08-27)
MLL1 belongs to the SET1 family of histone H3 lysine 4 (H3K4) methyltransferases, composed of MLL1-4 and SETd1A/B. MLL1 translocations are present in acute leukemias, and mutations in several family members are associated with cancer and developmental disorders. MLL1 associates
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