AEE788 is an orally available and potent dual family of human EGFR and VEGFR receptor tyrosine kinase inhibitor that exhibits potent antitumor and antiangiogenic activity.
AEE788 is an orally available and potent dual family of human EGFR and VEGFR receptor tyrosine kinase inhibitor.
International journal of molecular sciences, 20(10) (2019-05-28)
Inhibiting the tyrosine kinase activity of epidermal growth factor receptor (EGFR) using small molecule tyrosine kinase inhibitors (TKIs) is often ineffective in treating cancers harboring wild-type EGFR (wt-EGFR). TKIs are known to cause dimerization of EGFR without altering its expression
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