SAB4700031

Monoclonal Anti-CD1A-PE antibody produced in mouse

clone HI149, purified immunoglobulin, buffered aqueous solution

• UNSPSC Code: 12352203
• NACRES: NA.44

Properties

• biological source: mouse
• Quality Level: 100
• conjugate: phycoerythrin (R-PE) conjugate
• antibody form: purified immunoglobulin
• antibody product type: primary antibodies
• clone: HI149, monoclonal
• form: buffered aqueous solution
• species reactivity: human
• technique(s): flow cytometry: suitable
• isotype: IgG1
• NCBI accession no.: NM_001763.2
• UniProt accession no.: P06126
• shipped in: wet ice
• storage temp.: 2-8°C
• target post-translational modification: unmodified
• Gene Information: human ... CD1A(909)

Description

General description

CD1a molecule is a lipid-presenting protein, which is highly expressed on Langerhans cells. It belongs to the CD1 protein family and is encoded by the gene mapped to human chromosome 1.

The antibody HI149 reacts with CD1a (T6), a 49 KDa polypeptide associated with beta2-microglobulin expressed on cortical thymocytes (strongly), Langerhans cells, dendritic cells and some T cell leukemias and lymphomas. The antibody does not react with peripheral blood T and B lymphocytes, monocytes, granulocytes, platelets and erythrocytes.

Immunogen

Human thymocytes

Application

The reagent is designed for Flow Cytometry analysis of human blood cells using 20 μL reagent / 100 μL of whole blood or 1e6 cells in a suspension. The content of a vial (2 mL) is sufficient for 100 tests.

Biochem/physiol Actions

CD1a acts as a potential target for treatment against inflammatory skin diseases. The encoded protein functions as a phenotypic marker of human epidermal Langerhans cells (LC). CD1a mediates the presentation of lipids to induce T cell activation resulting in the production of interleukin-22 (IL-22), IL-13 and interferon (IFN)γ.

Features and Benefits

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Physical form

Solution in phosphate buffered saline containing 15 mM sodium azide and 0.2% high-grade protease free BSA as a stabilizing agent.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 2
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable