NTRK2 (neurotrophic tyrosine kinase receptor type 2) is also known as TRKB (tropomyosin receptor kinase B). It belongs to the Trk family of neurotrophin receptors. The NTRK2 gene is located on human chromosome 9q21.32.
Immunogen
The antiserum was produced against synthesized peptide derived from human Trk B around the phosphorylation site of Tyr705.
Immunogen Range: 671-720
Biochem/physiol Actions
In NB (neuroblastoma), NTRK2 (neurotrophic tyrosine kinase receptor type 2) controls the favorable and unfavorable clinical actions. It also controls the roles of glutamate receptor and synaptic plasticity in the amygdala.
Features and Benefits
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Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
A common NTRK2 variant is associated with emotional arousal and brain white-matter integrity in healthy young subjects
Spalek K, et al.
Translational Psychiatry (2016)
Entrectinib is a potent inhibitor of Trk-driven neuroblastomas in a xenograft mouse model
Iyer R, et al.
Cancer Letters, 372(2), 179-186 (2016)
Case Report: Next generation sequencing identifies a NAB2-STAT6 fusion in Glioblastoma
Diamandis P, et al.
Diagnostic Pathology (2016)
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