SAB4300083

Anti-phospho-GRIN1 (pSer⁸⁹⁶) antibody produced in rabbit

affinity isolated antibody

• Synonym(s): Anti-NMDA1 antibody produced in rabbit, Anti-NMDAR1 antibody produced in rabbit, Anti-NR1 antibody produced in rabbit, Anti-glutamate receptor, ionotropic, N-methyl D-aspartate 1 antibody produced in rabbit
• MDL number: MFCD00282329
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: rabbit
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: ~120 kDa
• species reactivity: human, mouse, rat
• concentration: 1 mg/mL
• technique(s): western blot: 1:500-1:1000
• isotype: IgG
• immunogen sequence: (R-R-SP-S-K)
• NCBI accession no.: NP_000823.4
• UniProt accession no.: Q05586
• shipped in: wet ice
• storage temp.: −20°C
• target post-translational modification: phosphorylation (pSer896)
• Gene Information: human ... GRIN1(2902)

Description

Immunogen

Peptide sequence around phosphorylation site of serine 896 (R-R-S(p)-S-K), according to the protein GRIN1.

Features and Benefits

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Target description

NMDA receptors are members of the ionotropic class of glutamate receptors, which also includes Kainate and AMPA receptors. NMDA receptors consist of NR1 subunits combined with one or more NR2 (A-D) or NR3 (A-B) subunits. The ligand-gated channel is permeable to cations including Ca2+, and at resting membrane potentials NMDA receptors are inactive due to a voltage-dependent blockade of the channel pore by Mg2+. NMDA receptor activation, which requires binding of glutamate and glycine, leads to an influx of Ca2+ into the postsynaptic region where it activates several signaling cascades, including pathways leading to the induction of long-term potentiation (LTP) and depression (LTD). NMDA receptors have a critical role in excitatory synaptic transmission and plasticity in the CNS. They govern a rangeof physiological conditions including neurological disorders caused by excitotoxic neuronal injury, psychiatric disorders and neuropathic pain syndromes.

Physical form

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable