SAB4200243

Anti-MAN1C1 (internal) antibody produced in rabbit

~1.0 mg/mL, affinity isolated antibody

• Synonym(s): Anti-1,2-alpha-mannosidase IC, Anti-HMIC, Anti-MAN1A3, Anti-MAN1C, Anti-mannosidase, alpha, class 1C, member 1, Anti-pp6318, Anti-processing alpha-1,2-mannosidase IC
• UNSPSC Code: 12352203

Properties

• biological source: rabbit
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: ~71 kDa
• species reactivity: human, rat
• concentration: ~1.0 mg/mL
• UniProt accession no.: Q9NR34
• shipped in: dry ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... MAN1C1(57134) ; rat ... Man1c1(362625)

Description

General description

Anti- MAN1C1 (internal) is produced in rabbit using as immunogen a synthetic peptide of human MAN1C1 conjugated to KLH. Mannosidase α, class 1C, member 1 (MAN1C1), also known as MAN1A3, is a member of the glycosyl hydrolase 47 family. MAN1C1 is a type II membrane protein with sequence similarity to class I α1,2- mannosidases, which localizes to the Golgi apparatus membrane. MAN1C1 trims α-1,2-linked mannose residues from Man₉GlcNAc₂ to produce the Man₅GlcNAc₂ processing intermediate.

MAN1C1 is encoded by the gene mapped to human chromosome 1p36.11.

Specificity

Anti-MAN1C1 (internal) recognizes human and rat MAN1C1.

Application

Anti-MAN1C1 (internal) antibody produced in rabbit has been used in immunoblotting.

Biochem/physiol Actions

Altered expression of the MAN1C1 gene may lead to meningioma progression and recurrence.

Mannosidase α, class 1C, member 1 (MAN1C1) is involved in the maturation of Asn-linked oligosaccharides and quality control. MAN1C1 over-expression accelerates endoplasmic reticulum-associated protein degradation (ERAD) of terminally misfolded human null Hong Kong α1-antitrypsin.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide

Storage and Stability

Store at –20 °C. For continuous use, store at 2–8 °C for up to one month. For extended storage freeze in working aliquots. Repeated freezing and thawing is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.

Disclaimer

Unless otherwise stated in our catalog, our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class Code: 10 - Combustible liquids
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable