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Key Documents

SAB2500149

Sigma-Aldrich

Anti-BAK1 antibody produced in goat

affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-BAK, Anti-BCL2-antagonist/killer 1, Anti-BCL2L7, Anti-CDN1

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About This Item

MDL number:
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

goat

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

human, rat, mouse

technique(s)

indirect ELISA: suitable
western blot: suitable

UniProt accession no.

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... BAK1(578)

General description

BCL2 antagonist/killer 1 (BAK1) is part of the BCL-2 family of apoptosis regulators. It is a pro-apoptotic protein. The gene encoding BAK1 is localized on human chromosome 6p21.33.

Immunogen

Peptide with sequence ASGQGPGPPRQE-C from the N Terminus of the protein sequence according to NP_001179.

Biochem/physiol Actions

BCL2 antagonist/killer 1 (BAK1) modulates the lifespan of platelets. It has been associated with dengue hemorrhagic fever. BAK1 promotes the opening of the mitochondrial voltage-dependent anion channel and aids the release of cytochrome c.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Supplied at 0.5 mg/mL in Tris saline with 0.02% sodium azide and 0.5% bovine serum albumin.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Precautionary Statements

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2

Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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Putative roles of mitochondrial Voltage-Dependent Anion Channel, Bcl-2 family proteins and c-Jun N-terminal Kinases in ischemic stroke associated apoptosis
Rajeev Gupta
Biochimie (2017)
Association of BAK1 single nucleotide polymorphism with a risk for dengue hemorrhagic fever.
Dang TN
BMC Medical Genetics (2016)
Comparative analysis in cynomolgus macaque identifies a novel human MHC locus controlling platelet blood counts independently of BAK1.
Aarnink A
Journal of Thrombosis and Haemostasis (2013)
Common variation at 6p21.31 (BAK1) influences the risk of chronic lymphocytic leukemia
Susan L
Blood (2012)

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