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S8201

Sigma-Aldrich

SR-3576

≥98% (HPLC)

Synonym(s):

3-(5-(3-m-Tolylureido)-1H-indazol-1-yl)-N-(3,4,5-trimethoxyphenyl)benzamide, 3-[4-[[[(3-Methylphenyl)amino]carbonyl]amino]-1H-pyrazol-1-yl]-N-(3,4,5-trimethoxyphenyl)-benzamide

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About This Item

Empirical Formula (Hill Notation):
C27H27N5O5
CAS Number:
1164153-22-3
Molecular Weight:
501.53
MDL number:
MFCD18632556
UNSPSC Code:
12352200
PubChem Substance ID:
329824599
NACRES:
NA.77

Assay

≥98% (HPLC)

form

powder

color

light brown to brown

solubility

DMSO: ≥20 mg/mL

storage temp.

2-8°C

SMILES string

COc1cc(NC(=O)c2cccc(c2)-n3cc(NC(=O)Nc4cccc(C)c4)cn3)cc(OC)c1OC

InChI

1S/C27H27N5O5/c1-17-7-5-9-19(11-17)30-27(34)31-21-15-28-32(16-21)22-10-6-8-18(12-22)26(33)29-20-13-23(35-2)25(37-4)24(14-20)36-3/h5-16H,1-4H3,(H,29,33)(H2,30,31,34)

InChI key

MTFAYLZZDJGFGV-UHFFFAOYSA-N

Application

SR-3576 may be used in JNK3-mediated cell signaling studies.

Biochem/physiol Actions

SR-3576 is a cell-permeable, potent and selective JNK3 (c-Jun N-terminal kinase 3) inhibitor.
SR-3576 is a small molecule inhibitor belonging to aminopyrazole class that selectively inhibits JNK3 with >2800 fold selectively over p38.1

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Ted Kamenecka et al.
The Journal of biological chemistry, 284(19), 12853-12861 (2009-03-06)
c-Jun N-terminal kinase 3alpha1 (JNK3alpha1) is a mitogen-activated protein kinase family member expressed primarily in the brain that phosphorylates protein transcription factors, including c-Jun and activating transcription factor-2 (ATF-2) upon activation by a variety of stress-based stimuli. In this study
Mei-Chou Lai et al.
Nutrients, 15(3) (2023-02-12)
Degenerative diseases of the brain include Parkinson's disease (PD), which is associated with moveable signs and is still incurable. Hispidin belongs to polyphenol and originates primarily from the medicinal fungi Inonotus and Phellinus, with distinct biological effects. In the study
Sara Barreto et al.
Acta biomaterialia, 53, 59-69 (2017-02-22)
In order to identify the mechanisms by which skeletal maturity alters the mechanosensitivity of mesenchymal stromal cells (MSCs) and, the implications for osteogenesis and angiogenesis during bone formation, we compared the response of MSCs derived from children and skeletally-mature healthy

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