PZ0178

PHA 767491 hydrochloride

≥98% (HPLC)

• Synonym(s): 1,5,6,7-Tetrahydro-2-(4-pyridinyl)-4H-pyrrolo[3,2-c]pyridin-4-one hydrochloride, 2-Pyridin-4-yl-1,5,6,7-tetrahydro-pyrrolo[3,2-c]pyridin-4-one hydrochloride, PHA-00767491 hydrochloride
• Empirical Formula (Hill Notation): C₁₂H₁₁N₃O · xHCl
• CAS Number: 845538-12-7
• Molecular Weight: 213.24 (free base basis)
• MDL number: MFCD11519962
• UNSPSC Code: 51111800
• PubChem Substance ID: 329823752
• NACRES: NA.77

Properties

• Assay: ≥98% (HPLC)
• form: powder
• storage condition: desiccated
• color: off-white to yellow
• solubility: H₂O: >25 mg/mL
• SMILES string: Cl.O=C1NCCc2[nH]c(cc12)-c3ccncc3
• InChI: 1S/C12H11N3O.ClH/c16-12-9-7-11(8-1-4-13-5-2-8)15-10(9)3-6-14-12;/h1-2,4-5,7,15H,3,6H2,(H,14,16);1H
• InChI key: IMVNFURYBZMFDZ-UHFFFAOYSA-N

Description

Application

PHA 767491 hydrochloride has been used to study its effect on estrogen-induced DNA damage. It has also been used in western blot analysis and to study the S9.6 nuclear signal in HeLa cells.

Biochem/physiol Actions

PHA 767491 serves as a potential anticancer drug. It shows an ameliorating effect against acute myeloid leukemia, colon and breast cancer models. PHA 767491 possesses anti proliferating and apoptotic effect.

PHA-767491 is a potent and selective ATP-competitive dual inhibitor cdc7/cdk9. PHA-767491 blocks DNA synthesis and affects the phosphorylation of the replicative DNA helicase at Cdc7-dependent phosphorylation sites.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable