P7872

Anti-Prostaglandin D₂ Receptor antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

• MDL number: MFCD06798519
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: rabbit
• Quality Level: 200
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• species reactivity: human
• availability: not available in Japan
• technique(s): immunohistochemistry (formalin-fixed, paraffin-embedded sections): 4-7 μg/mL using colon epithelium
• UniProt accession no.: Q13258
• shipped in: dry ice
• storage temp.: −20°C
• Gene Information: human ... PTGDR(5729) ; mouse ... Ptgdr(19214) ; rat ... Ptgdrl(63889)

Description

General description

Prostaglandin D2 receptor (PTGDR) is encoded by the gene mapped to human chromosome 14q22.1. This receptor is mainly localized on immune cells. In addition, it is also expressed in platelets, cells of the central nervous system, ciliated and non-ciliated bronchial cells and alveolar epithelial type I and type II cells.

Immunogen

synthetic peptide corresponding to the third extracellular loop of human protaglandin D2 receptor. The immunizing peptide has ~80% homology with both the rat and mouse gene.

Biochem/physiol Actions

Prostaglandin D2 receptor (PTGDR) gene acts as a promising target for DNA methylation in advanced types of neuroblastoma (NB). The encoded protein is implicated in pulmonary vasodilation, bronchoconstriction, recruitment of eosinophils, basophils and T-lymphocytes. In addition, it also stimulates the synthesis of leukotriene C4. The gene expression has been associated with asthma.

Target description

Prostaglandin D₂ Receptor gene encodes a protein that is a G-protein-coupled receptor. It has been shown to function as a prostanoid DP receptor. The activity of this receptor is mainly mediated by G-S proteins that stimulate adenylate cyclase

Physical form

Solution in phosphate buffered saline, pH 7.7, containing 0.1% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class Code: 10 - Combustible liquids
• WGK: nwg
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable