P7412

Pirenzepine dihydrochloride

≥98% (TLC), powder

• Synonym(s): 5,11-Dihydro-11-[(4-methyl-1-piperazinyl)acetyl]-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one dihydrochloride
• Empirical Formula (Hill Notation): C₁₉H₂₁N₅O₂ · 2HCl
• CAS Number: 29868-97-1
• Molecular Weight: 424.32
• EC Number: 249-907-5
• MDL number: MFCD00055214
• UNSPSC Code: 12352200
• PubChem Substance ID: 24277863
• NACRES: NA.77

Properties

• Assay: ≥98% (TLC)
• form: powder
• color: white
• solubility: H₂O: 50 mg/mL
• SMILES string: Cl[H].Cl[H].CN1CCN(CC1)CC(=O)N2c3ccccc3C(=O)Nc4cccnc24
• InChI: 1S/C19H21N5O2.2ClH/c1-22-9-11-23(12-10-22)13-17(25)24-16-7-3-2-5-14(16)19(26)21-15-6-4-8-20-18(15)24;;/h2-8H,9-13H2,1H3,(H,21,26);2*1H
• InChI key: FFNMBRCFFADNAO-UHFFFAOYSA-N
• Gene Information: human ... CHRM1(1128)

Description

General description

Pirenzepine dihydrochloride is an anticholinergic agent. It is also considered as an antiulcer drug. It is used to treat myopia, gastric and duodenal ulcers. Pirenzepine dihydrochloride induces the dimerization of muscarinic M1 receptors.

Application

Pirenzepine dihydrochloride has been used

• in transactivation of fibroblast growth factor receptor (FGFR).
• as a supplement in cell culture.
• for the stimulation of human fibroblasts

Biochem/physiol Actions

Selective M₁ muscarinic acetylcholine receptor antagonist.

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Acetylcholine Receptors (Muscarinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Caution

Hygroscopic; store desiccated at room temperature.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 2
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves