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M5560

Sigma-Aldrich

(S)-2-Amino-2-methyl-4-phosphonobutyric acid hydrochloride

synthetic, solid

Synonym(s):

(S)-MAP4 hydrochloride

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About This Item

CAS Number:
844864-14-8
MDL number:
MFCD06804601
UNSPSC Code:
12352200
PubChem Substance ID:
24277822

biological source

synthetic

Quality Level

100

form

solid

color

white

SMILES string

Cl.C[C@](N)(CCP(O)(O)=O)C(O)=O

InChI

1S/C5H12NO5P.ClH/c1-5(6,4(7)8)2-3-12(9,10)11;/h2-3,6H2,1H3,(H,7,8)(H2,9,10,11);1H/t5-;/m0./s1

InChI key

DNFXUQUECNSSJF-JEDNCBNOSA-N

Gene Information

human ... GRM4(2914) , GRM6(2916) , GRM7(2917)

Biochem/physiol Actions

Selective mGluR4,6,7 metabotropic glutamate receptor antagonist.

Features and Benefits

This compound is featured on the Glutamate Receptors (G Protein Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319,H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
090K4714
032K4710

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T E Salt et al.
Neuroscience, 65(1), 5-13 (1995-03-01)
A variety of metabotropic excitatory amino acid receptors are present in the thalamus. We have investigated the possibility that some of these receptors may have presynaptic effects on GABAergic inhibitory transmission in the thalamus. Inhibitory responses in ventrobasal thalamic neurons
T Knöpfel et al.
Neuropharmacology, 34(8), 1099-1102 (1995-08-01)
The two reported metabotropic glutamate receptor (mGluR) antagonists, alpha-methyl-cyclopropyl glycine (MCCG) and alpha-methyl-aminophosphonobutyrate (MAP4) were tested on the mGluR1b, mGluR2 and mGluR4a subtypes of human mGluRs. Neither MCCG (500 microM) nor MAP4 (500 microM) antagonized the activation of mGluR1b by

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