This product is synthetic melanin, per Med. Res. Reviews 8 (1988) pp. 525-556, synthetic melanins are "eumelanin type pigments". Unfortunately, no additional information on the level of polymerization is available.
M0418
Melanin
BioReagent, Synthetic, suitable for cell culture
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About This Item
Pricing and availability is not currently available.
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biological source
synthetic
product line
BioReagent
Assay
≥97% (TLC)
form
powder
technique(s)
cell culture | mammalian: suitable
solubility
1 N NH4OH: 20 mg/mL
storage temp.
−20°C
SMILES string
[nH]1c2c3c(c4c5c([nH]c4)c([c]([c](c5c3c1)=O)=O)C)[c]([c](c2C)=O)=O
InChI
1S/C18H10N2O4/c1-5-13-9-7(3-19-13)12-10-8(11(9)17(23)15(5)21)4-20-14(10)6(2)16(22)18(12)24/h3-4,19-20H,1-2H3
InChI key
XUMBMVFBXHLACL-UHFFFAOYSA-N
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General description
Melanin is a distinctive class of pigment found in animals, plants, bacteria, and fungi. It is an amorphous polymer formed by the polymerization of phenolic and indolic compounds.
Application
Melanin has been used:
- to incubate normal human keratinocytes for Masson-Fontana staining
- as a standard in the determination of melanin content in normal human epidermal melanocytes and immortalized human keratinocytes
- as an absorber to mimic human skin or melanocytic nevi and melanoma
Biochem/physiol Actions
Melanin plays a role in camouflage and energy harvesting. It also helps in protection against ionizing UV radiations, protection against biotic factors such as host defense against pathogens, and abiotic factors like heat, cold and osmotic stress. Melanin acts as a potent cation chelator and is a component of several photoprotective creams as it facilitates free radical scavenging activity. Melanin may be useful as a photo protectant in cell culture.
Preparation Note
Prepared by oxidation of tyrosine with hydrogen peroxide.
Storage Class Code
11 - Combustible Solids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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I wonder if you can let me know what type of melanin pigment this reagent has. Is it pheo-, eu- or mixed melanin? What is the level of polymerization? Thank you!
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