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L4045

Sigma-Aldrich

Luotonin A

≥98% (HPLC)

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About This Item

Linear Formula:
C18H11N3O
CAS Number:
Molecular Weight:
285.30
UNSPSC Code:
12352202
NACRES:
NA.77

biological source

synthetic (organic)

Assay

≥98% (HPLC)

form

solid

solubility

chloroform: methanol (1:1): 4 mg/mL, clear to slightly hazy, colorless to yellow

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... TOP1(7150)

Biochem/physiol Actions

Luotonin A is a cytotoxic alkaloid reported to inhibit topoisomerase I. Luotonin A was originally isolated from the Chinese medicinal plant Paganum nigellastrum. As an antitumor agent, Luotonin A demonstrates cytotoxic activity against the mouse leukemic cell line P-388 at low concentrations (IC50 1.8μg/mL). Luotonin A stabilizes the cleavable human topoisomerase I-DNA binary complex resulting in cytotoxicity to cells (IC50 5.07-12.6 μM).Luotonin forms non-covalent complexes with ds-DNA in the minor groove. It may serve as a prototype for analytical probes of DNA hybridization.

Reconstitution

Solubility is tested at 4 mg/mL in 1:1 solution of choloform and methanol. Solubility of luotonins in DMSO has been reported.

Pictograms

Skull and crossbones

Signal Word

Danger

Hazard Statements

Precautionary Statements

Hazard Classifications

Acute Tox. 3 Oral

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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Pierluigi Mussardo et al.
Analytical and bioanalytical chemistry, 400(2), 321-327 (2011-01-19)
The interaction between DNA and several newly synthesized derivatives of the natural anticancer compound luotonin A has been studied. The results from our work reveal an effective and selective alkaloid/double-stranded DNA (ds-DNA) interaction. In the presence of increasing amounts of

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