Skip to Content
Merck
All Photos(2)

Key Documents

L1294

Sigma-Aldrich

Lactoferrin human

recombinant, expressed in rice, Iron saturated, ≥90% (SDS-PAGE)

Synonym(s):

Holo Transferrin

Sign Into View Organizational & Contract Pricing
All Photos(2)

About This Item

MDL number:
MFCD00164307
UNSPSC Code:
12352202
NACRES:
NA.25
Pricing and availability is not currently available.

biological source

human

recombinant

expressed in rice

type

for cell culture

Assay

≥90% (SDS-PAGE)
≥90% (biuret)

form

powder

technique(s)

microbiological culture: suitable

impurities

≤10 EU/mg endotoxin

UniProt accession no.

P02788

storage temp.

2-8°C

Gene Information

human ... LTF(4057)

Looking for similar products? Visit Product Comparison Guide

Application

Lactoferrin was used to grow Streptococcus mutans in an iron-limiting medium.[1] It was used to test if lactoferrin impedes epithelial cell adhesion in vitro.[2]

Biochem/physiol Actions

Lactoferrin is an iron binding protein. It is structurally similar to transferrin, the plasma iron transport protein; but lactoferrin has a much higher affinity for iron (250 fold). It is very abundant in colostrum and small amounts can also be found in tears, saliva, mucous secretions and in the secondary granules of neutrophils. It is made by mucosal epithelium and neutrophils and is released by these cells in response to inflammatory stimuli. Bacterial growth is inhibited by its ability to sequester iron and also permeabilize bacterial cell walls by binding to lipopolysaccharides through its N-terminus. Lactoferrin can inhibit viral infection by binding tightly to the viral envelope protein. This prevents cell-virus fusion by blocking the binding domain. Lactoferrin appears to activate host defense systems in part by stimulating the release of interleukin-8, a neutrophil activator. It may also be involved in antibody and interleukin synthesis, lymphocyte proliferation and complement activation.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

It looks like we've run into a problem, but you can still download Certificates of Analysis from our Documents section.

If you need assistance, please contact Customer Support.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Erwann Rousseau et al.
Molecular pharmacology, 84(6), 888-898 (2013-10-01)
Previous studies on postmortem human brain tissue have shown that the iron-binding glycoprotein lactoferrin is upregulated in dopamine (DA) neurons resistant to degeneration in Parkinson disease (PD). To study how this could possibly relate to disease progression, we used midbrain
N Huang et al.
In vitro cellular & developmental biology. Animal, 44(10), 464-471 (2008-09-20)
Today there is a concern about the use of animal source proteins and peptides in cell culture applications due to potential contamination by adventitious infectious pathogens. Recombinant production of these proteins using a plant host provides a safe and cost
Ling Tang et al.
Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society, 18(1), 123-131 (2010-01-20)
Human lactoferrin (hLF), a glycoprotein of the transferrin family, has recently been shown to stimulate wound repair through its antimicrobial effect and inflammation modulation. A recent study with several non-skin cell lines indicated that hLF may also have a stimulatory
Uxía Regueiro et al.
International journal of molecular sciences, 23(20) (2022-10-28)
Keratoconus (KC) is a corneal disorder whose etiology shares a close relationship with Lactoferrin (LTF) dysregulation and Toll-like Receptors 2 (TLR2) overexpression. This study shows how these two important biomarkers are clinically and molecularly interrelated, increasing knowledge about KC pathophysiology
Esmat Aly et al.
Food research international (Ottawa, Ont.), 118, 101-107 (2019-03-23)
This study aimed to evaluate the potential anti-inflammatory role of the most produced form of lactoferrin expressed in various expression systems (Fe-saturated recombinant human Lf, rhLf) and its hydrolysate in concentrations resembles that found in mature human milk. Co-culture model
View All Related Papers

Questions

1–3 of 3 Questions  

  1. what is the molecular weight of L1294, Lactoferrin human?

    1 answer

    1. The molecular weight of this product is approximately 80 kDa.

      Helpful?

  2. Do you have a recommendation for storage after dissolving in H2O? I cannot find any handling instructions online.

    1 answer

    1. The stability of this item has not been tested once it is in solution. It is recommended to make fresh before using the item.

      Helpful?

  3. What is the sequence of this product? Do you have the half (1-11) peptide product?

    1 answer

    1. L1294, Lactoferrin human, has the exact same amino acid sequence as the native protein. Unfortunately, we do not supply human lactoferrin peptide hLF1-11.

      Helpful?

Reviews

No rating value

Active Filters

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service