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I2279

Sigma-Aldrich

IMID-4F hydrochloride

solid, solubility: >9 mg/mL in H2O, soluble

Synonym(s):

2-[N-(2,6-dichlorophenyl)-N-(4-fluorobenzyl)amino]-2-imidazoline hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C16H14Cl2FN3 ·HCl
CAS Number:
1049740-09-1
Molecular Weight:
374.67
MDL number:
MFCD03452939
UNSPSC Code:
12352202
PubChem Substance ID:
24278489
NACRES:
NA.77

Assay

≥98%

form

solid

color

white

solubility

H2O: soluble >9 mg/mL

SMILES string

Cl[H].Fc1cccc(CN(C2=NCCN2)c3c(Cl)cccc3Cl)c1

InChI

1S/C16H14Cl2FN3.ClH/c17-13-5-2-6-14(18)15(13)22(16-20-7-8-21-16)10-11-3-1-4-12(19)9-11;/h1-6,9H,7-8,10H2,(H,20,21);1H

InChI key

TWVCONNNZSKLLX-UHFFFAOYSA-N

Biochem/physiol Actions

Novel imidazoline-based K(ATP) channel blocker.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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G A McPherson et al.
British journal of pharmacology, 128(8), 1636-1642 (1999-12-10)
1. The functional and electrophysiological effects of IMID-4F (2-[N-(2, 6-dichlorophenyl)-N-(4-flurorobenzyl)amino]imidazoline), a fluoro-benzyl derivative of clonidine, on vascular K(ATP) channels were investigated. In pig coronary artery, IMID-4F inhibited the vasorelaxation response to the K(ATP) channel opener levcromakalim with a pK(B) value
K Bell et al.
Naunyn-Schmiedeberg's archives of pharmacology, 362(2), 145-151 (2000-08-29)
In this study the activity of a number of novel imidazoline-based compounds (IMID series) was assessed by functional and binding studies to determine their actions at K(ATP) channels. The novel compounds, which we synthesised, were methoxy-, methyl-, butyl- and fluorophenyl

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