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I0782

Sigma-Aldrich

Imazodan

≥99% (HPLC)

Synonym(s):

4,5-Dihydro-6-[4-(1H-imidazol-1-yl)phenyl]-3(2H)-pyridazinone, Cl 914

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About This Item

Empirical Formula (Hill Notation):
C13H12N4O
CAS Number:
84243-58-3
Molecular Weight:
240.26
MDL number:
MFCD00867109
UNSPSC Code:
41106305
PubChem Substance ID:
24278485

Assay

≥99% (HPLC)

color

yellow, powder

solubility

DMSO: 50 mg/mL, clear, yellow

SMILES string

O=C1CCC(=NN1)c2ccc(cc2)-n3ccnc3

InChI

1S/C13H12N4O/c18-13-6-5-12(15-16-13)10-1-3-11(4-2-10)17-8-7-14-9-17/h1-4,7-9H,5-6H2,(H,16,18)

InChI key

VXMYWVMXSWJFCV-UHFFFAOYSA-N

Gene Information

human ... PDE3A(5139)
rat ... Pde3a(50678)

Biochem/physiol Actions

Selective phoshodiesterase III (PDE3) inhibitor.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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High-performance liquid chromatographic assay of imazodan, methylparaben and propylparaben in imazodan injection.
T Geria et al.
Journal of chromatography, 450(3), 407-413 (1988-10-26)
S E Sadler
Molecular endocrinology (Baltimore, Md.), 5(12), 1947-1954 (1991-12-01)
Insulin-like growth factor-I (IGF-I) stimulated Xenopus laevis oocyte ribosomal S6 kinase activity 5- to 10-fold, with an apparent EC50 of 0.8 +/- 0.1 nM after 90 min of hormone treatment. IGF-I-stimulated enzyme activity was inhibited by treatment of oocytes with
[Phosphodiesterase inhibition as a new positive-inotropic principle].
A Hartmann et al.
Deutsche medizinische Wochenschrift (1946), 111(51-52), 1971-1977 (1986-12-19)
Determination of 4,5-dihydro-6-[4-(1H-imidazol-1-yl) phenyl]-3(2H)-pyridazinone hydrochloride, a new cardiotonic, in plasma and urine by reversed-phase high-performance liquid chromatography.
A G Hayes et al.
Journal of chromatography, 336(2), 446-451 (1984-12-12)
R E Weishaar et al.
Cardiovascular drugs and therapy, 3(1), 29-42 (1989-03-01)
Intense efforts during the last decade to identify a useful positive inotropic agent to replace digitalis for the treatment of congestive heart failure have led to the discovery of several dozen potential substitutes, of which a number are currently undergoing
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