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H5270

Sigma-Aldrich

Hydrocortisone 17-butyrate

Synonym(s):

11β,17,21-Trihydroxypregn-4-ene-3,20-dione 17-butyrate, Cortisol 17-butyrate

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About This Item

Empirical Formula (Hill Notation):
C25H36O6
CAS Number:
13609-67-1
Molecular Weight:
432.55
EC Number:
237-093-4
MDL number:
MFCD00083364
UNSPSC Code:
41116107
PubChem Substance ID:
24895684
NACRES:
NA.77
Pricing and availability is not currently available.

form

solid

Quality Level

200

shipped in

ambient

storage temp.

room temp

SMILES string

[H][C@@]12CCC3=CC(=O)CC[C@]3(C)[C@@]1([H])[C@@H](O)C[C@@]4(C)[C@@]2([H])CC[C@]4(OC(=O)CCC)C(=O)CO

InChI

1S/C25H36O6/c1-4-5-21(30)31-25(20(29)14-26)11-9-18-17-7-6-15-12-16(27)8-10-23(15,2)22(17)19(28)13-24(18,25)3/h12,17-19,22,26,28H,4-11,13-14H2,1-3H3/t17-,18-,19-,22+,23-,24-,25-/m0/s1

InChI key

BMCQMVFGOVHVNG-TUFAYURCSA-N

Gene Information

human ... NR3C1(2908)

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Application

Hydrocortisone 17-butyrate may be used:
  • in the synthesis of hydrocortisone butyrate (HB)-loaded poly(d,l-lactic-co-glycolic acid) (PLGA) nanoparticles[1]
  • as a topical corticosteroid (CS) to study its effects on keratinocyte proliferation in hyperproliferant keratinocytes (HaCaT) model[2]
  • in the preparation of solid lipid nanoparticles (SLN)[3]

Biochem/physiol Actions

Hydrocortisone 17-butyrate is a corticosteroid[4] that acts as a dermocorticoid due to its application in dermatological therapy.[5] It exhibits therapeutic effects against vitiligo of the face and neck.[6]

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
0000259192
040H0863

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M Caproni et al.
Clinical and experimental dermatology, 31(6), 813-817 (2006-10-17)
Topical tacrolimus represents an effective and well-tolerated treatment for atopic dermatitis (AD). Its known effects include reduced production of proinflammatory cytokines and reduced chemokine gradient. We performed lesional skin biopsies on adult patients affected by moderate-to-severe AD. Then, patients were
Robert Matheson et al.
Journal of drugs in dermatology : JDD, 7(3), 266-271 (2008-04-03)
Hydrocortisone butyrate (HCB) is currently marketed as a cream, ointment, and solution. A new lotion formulation of hydrocortisone butyrate 0.1% (Locoid lotion) has been developed and evaluated. The objective of this study was to evaluate the efficacy and safety of
Hidemi Nakagawa
Clinical drug investigation, 26(5), 235-246 (2006-12-14)
Tacrolimus (FK506) ointment is widely used in the treatment of patients with atopic dermatitis. The drug exerts its action by down-regulating antigen-specific T-cell activities and associated proinflammatory cytokine production. A number of clinical studies have evaluated the efficacy and safety
F Sassi et al.
The British journal of dermatology, 159(5), 1186-1191 (2008-08-23)
Vitiligo is a pigmentary disorder which may have disfiguring consequences. Its treatment remains a challenge. We designed a parallel-group randomized controlled trial to compare the effectiveness of 308-nm excimer laser alone or in combination with topical hydrocortisone 17-butyrate cream in
S Reitamo et al.
The British journal of dermatology, 152(6), 1282-1289 (2005-06-14)
Atopic dermatis (AD) is a chronic disease that often requires long-term treatment. Topical corticosteroids are the usual therapy for patients with AD, but prolonged usage can result in skin atrophy and other side-effects. In a randomized, double-blind, comparative study, to
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