H2917
Hexokinase-2 human
1 mg/mL, buffered aqueous glycerol solution
Synonym(s):
DKFZp686M1669, HK II, HK2, HXK2, Hexokinase type II, Muscle form hexokinase
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About This Item
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recombinant
expressed in E. coli
form
buffered aqueous glycerol solution
specific activity
3-4 units/mL
mol wt
104.1 kDa
concentration
1 mg/mL
relevant disease(s)
cancer
shipped in
wet ice
storage temp.
−20°C
General description
Hexokinase 2 is the predominant form found in skeletal muscle.
Hexokinases phosphorylate glucose to produce glucose-6-phosphate, thus committing glucose to the glycolytic pathway. Hexokinase 2 is the predominant form found in skeletal muscle.
Application
Hexokinase 2 (HK2) is a glycolytic enzyme that is crucial for the Warburg effect, which is the increased rate of glycolysis seen in rapidly growing cancer cells. HK2 may be used in cancer research to study human glioblastoma multiforme (GBM), which is the most common malignant brain tumor [1]. HK2 may be a potential therapeutic target for breast cancer as HK2 overexpression is associated with metastasis to the brain [2].
Biochem/physiol Actions
Hexokinases phosphorylate glucose to produce glucose-6-phosphate, thus committing glucose to the glycolytic pathway. Hexokinase 2 is involved in glucose metabolism and apoptosis [2].
Unit Definition
One unit will produce 1.0 μmole NADPH per minute as glucose is phosphorylated by ATP at pH 7.4 at 30 deg C.
Physical form
Supplied in a solution containing 20 mM Tris pH 8.0 and 10% glycerol.
Storage Class Code
10 - Combustible liquids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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Amparo Wolf et al.
The Journal of experimental medicine, 208(2), 313-326 (2011-01-19)
Proliferating embryonic and cancer cells preferentially use aerobic glycolysis to support growth, a metabolic alteration commonly referred to as the "Warburg effect." Here, we show that the glycolytic enzyme hexokinase 2 (HK2) is crucial for the Warburg effect in human
Diane Palmieri et al.
Molecular cancer research : MCR, 7(9), 1438-1445 (2009-09-03)
Brain metastases of breast cancer seem to be increasingin incidence as systemic therapy improves. Metastatic disease in the brain is associated with high morbidity and mortality. We present the first gene expression analysis of laser-captured epithelial cells from resected human
Yi Zhang et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(16), 6885-6894 (2013-04-19)
MicroRNAs (miRNAs) regulate dendritogenesis and plasticity. However, the biological function of miRNAs in axons has not been extensively investigated. Here, using rat primary cortical neurons cultured in a microfluidic chamber, we found that the distal axons of the neurons expressed
Jonathan Strosberg
Best practice & research. Clinical gastroenterology, 26(6), 755-773 (2013-04-16)
The prevalence of intestinal neuroendocrine tumours, also known as carcinoid tumours, has increased significantly over the past three decades. Tumours of the distal small intestine (midgut) are often indolent, but are characterized by a high potential to metastasize to the
Young-Mi Ham et al.
Experimental cell research, 319(10), 1451-1462 (2013-04-10)
The AKT and ERK signaling pathways are known to be involved in cell hypertrophy, proliferation, survival and differentiation. Although there is evidence for crosstalk between these two signaling pathways in cellulo, there is less evidence for cross talk in vivo.
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