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GW22767

Sigma-Aldrich

Anti-FAS (ab2) antibody produced in chicken

affinity isolated antibody, buffered aqueous solution

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About This Item

MDL number:
MFCD00283209
UNSPSC Code:
12352203
NACRES:
NA.41
Pricing and availability is not currently available.

biological source

chicken

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

human

manufacturer/tradename

Genway 15-288-22767

technique(s)

western blot: suitable

NCBI accession no.

NP_000034.1

UniProt accession no.

P25445

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... FAS(355)

Immunogen

Immunogen Sequence: GI # 4507583, sequence 191-335
Recombinant tumor necrosis factor receptor superfamily, member 6 isoform 1

Application

Anti-FAS (ab2) antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.

Biochem/physiol Actions

The FAS receptor (FasR) is a protein encoded by the TNFRSF6 gene in humans and is mapped to chromosomal band 10q24.1. It is a cell surface antigen expressed on a variety of normal and malignant cells. It is also associated with programmed cell death (apoptosis). Mutation of the gene or defective FAS signaling may render the T-cell lymphoblastic lymphomas (T-LBLs) tumor cells resistant to apoptotic cell death.[1]

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
029K2109
049K0523

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M Villa-Morales et al.
Cell death & disease, 5, e1110-e1110 (2014-03-08)
The acquisition of resistance towards FAS-mediated apoptosis may be required for tumor formation. Tumors from various histological origins exhibit FAS mutations, the most frequent being hematological malignancies. However, data regarding FAS mutations or FAS signaling alterations are still lacking in
Assignment of the human Fas antigen gene (Fas) to 10q24.1.
J Inazawa et al.
Genomics, 14(3), 821-822 (1992-11-01)
P Lichter et al.
Genomics, 14(1), 179-180 (1992-09-01)
The APO-1 (APT) antigen is a cell surface antigen expressed on a variety of normal and malignant cells. Binding of anti-APO-1 antibody to the APO-1 antigen induces programmed cell death (apoptosis). The APO-1 antigen shows homology to the members of

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