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G9910

Sigma-Aldrich

Sodium glycodeoxycholate

BioXtra, ≥97% (HPLC)

Synonym(s):

3α,12α-Dihydroxy-5β-cholan-24-oic acid N-(carboxymethyl)amide, Glycodeoxycholic acid sodium salt, Glycodesoxycholic acid, N-(3α,12α-Dihydroxy-24-oxocholan-24-yl)glycine

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About This Item

Empirical Formula (Hill Notation):
C26H42NNaO5
CAS Number:
16409-34-0
Molecular Weight:
471.61
EC Number:
240-455-4
MDL number:
MFCD00036742
UNSPSC Code:
12161900
PubChem Substance ID:
24895386
NACRES:
NA.25

description

anionic

product line

BioXtra

Assay

≥97% (HPLC)

mol wt

471.61 g/mol

impurities

≤0.0025% Phosphorus (P)
≤0.1% Insoluble matter

CMC

2.1 mM

solubility

H2O: 0.1 M, clear to slightly hazy, colorless to almost colorless

anion traces

chloride (Cl-): ≤1%
sulfate (SO42-): ≤0.05%

cation traces

Al: ≤0.0005%
Ca: ≤0.011%
Cu: ≤0.0005%
Fe: ≤0.001%
K: ≤0.005%
NH4+: ≤0.05%
Pb: ≤0.001%
Zn: ≤0.003%

SMILES string

[Na].[H][C@]12CC[C@@]3([H])[C@]4([H])CC[C@]([H])([C@H](C)CCC(=O)NCC(O)=O)[C@@]4(C)[C@@H](O)C[C@]3([H])[C@@]1(C)CC[C@@H](O)C2

InChI

1S/C26H43NO5.Na.H/c1-15(4-9-23(30)27-14-24(31)32)19-7-8-20-18-6-5-16-12-17(28)10-11-25(16,2)21(18)13-22(29)26(19,20)3;;/h15-22,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32);;/t15-,16-,17-,18+,19-,20+,21+,22+,25+,26-;;/m1../s1

InChI key

BMYWWGPEKRLDGW-ZXMGEDLUSA-N

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General description

Sodium glycodeoxycholate is a bile salt that can be used to form biomimicking environments.

Application

Sodium glycodeoxycholate has been used in a study to develop more similar mimetic intestinal fluids to physiological fluids than those developed by mixed bile salt systems (MBS). It has also been used in a study to investigate Ca2+ buffering capability of bile salt micelles.

Biochem/physiol Actions

Induces apoptosis in hepatocytes; may induce DNA cleavage.

Other Notes

Bile Salt

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Bile salt composition is secondary to bile salt concentration in determining hydrocortisone and progesterone solubility in intestinal mimetic fluids
Huda H Zughaid, et al.
International Journal of Pharmaceutics, 422, 7-7 (2012)
Raina Thakur et al.
Photochemistry and photobiology, 88(5), 1248-1255 (2012-05-23)
Photophysical properties of two widely used antibiotic fluoroquinolone drugs, namely Norfloxacin (NOR) and Ofloxacin (OFL) have been investigated in biomimicking environments formed by bile salts. Experimental results demonstrate that photophysical enhancement and fall of a particular prototropic species are sensitive
Domenico Trombetta et al.
Nutrients, 12(11) (2020-11-11)
Almond kernels contain phytochemicals with positive health effects in relation to heart disease, diabetes and obesity. Several studies have previously highlighted that almond cell wall encapsulation during digestion and particle size are factors associated with these benefits. In the present
Hu-He Chen et al.
Guang pu xue yu guang pu fen xi = Guang pu, 30(3), 748-752 (2010-05-26)
In the present article, NaGDC was used to study the Ca(2+)-buffering capability of bile salt micelles. NaGDC is a naturally occurring bile salt which constitutes approximately 10 molar percent of bile salt composition in gallbladder. The authors selected glycine conjugated
Laura M Sanchez et al.
PloS one, 11(3), e0149603-e0149603 (2016-03-19)
Biofilms are a ubiquitous feature of microbial community structure in both natural and host environments; they enhance transmission and infectivity of pathogens and provide protection from human defense mechanisms and antibiotics. However, few natural products are known that impact biofilm
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