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G8769

Sigma-Aldrich

D-(+)-Glucose solution

D-(+)-Glucose solution

45% in H2O, sterile-filtered, BioXtra, suitable for cell culture

Synonym(s):

D-Glucopyranose

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About This Item

Empirical Formula (Hill Notation):
C6H12O6
CAS Number:
50-99-7
Molecular Weight:
180.16
Beilstein:
1281608
EC Number:
200-075-1
MDL number:
MFCD00063774
UNSPSC Code:
12352201
PubChem Substance ID:
24895351
NACRES:
NA.75
Pricing and availability is not currently available.

sterility

sterile-filtered

Quality Level

200

product line

BioXtra

form

solution

concentration

45% in H2O

technique(s)

cell culture | mammalian: suitable

impurities

endotoxin, tested

SMILES string

OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@@H]1O

InChI

1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6+/m1/s1

InChI key

WQZGKKKJIJFFOK-DVKNGEFBSA-N

Gene Information

human ... PYGM(5837)

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General description

Glucose is the energy currency essential for physiological processes in the living cells. It serves as a precursor for glycoproteins, glycolipids and glycosaminoglycans.[1]

Application

D-(+)-Glucose solution has been used as a medium supplement:
  • in Dulbecco′s Modified Eagle Medium (DMEM) for culturing Flp-In  293 cells[2]
  • in dissection medium for coronal slices from rat brain[3]
  • in neurobasal medium for culturing hippocampi cells[4]

Provides the primary energy source for cell metabolism.

Biochem/physiol Actions

Glucose is a crucial component for the growth and maintenance of mammalian cells in in vitro conditions and is essential for productivity and quality.[5] Its high metabolic turnover favors osteoclast differentiation.[1] The levels of glucose modulate the migration and growth of tumor cells. HeLa cells display high mobility at low glucose levels.[6]

Other Notes

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
RNBM0965
RNBL9386
RNBL8851
RNBL7295
RNBL6948

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Investigation of the Influence of Glucose Concentration on Cancer Cells by Using a Microfluidic Gradient Generator without the Induction of Large Shear Stress
Ishida T, et al.
Micromachines, 7(9), 155-155 (2016)
Protein kinase C activation causes neurite retraction via cyclin D 1 and p60-katanin increase in rat hippocampal neurons
Korulu S, et al.
The European Journal of Neuroscience, 37(10), 1610-1619 (2013)
Chad A Dumstorf et al.
Molecular cancer therapeutics, 9(12), 3158-3163 (2010-10-26)
Enzastaurin (LY317615.HCl) is currently in a phase III registration trial for diffuse large B-Cell lymphoma and numerous phase II clinical trials. Enzastaurin suppresses angiogenesis and induces apoptosis in multiple human tumor cell lines by inhibiting protein kinase C (PKC) and
High glucose and low specific cell growth but not mild hypothermia improve specific r-protein productivity in chemostat culture of CHO cells
Vergara M, et al.
Testing, 13(8), e0202098-e0202098 (2018)
Glucose: an energy currency and structural precursor in articular cartilage and bone with emerging roles as an extracellular signaling molecule and metabolic regulator
Mobasheri A
Frontiers in Endocrinology, 3, 153-153 (2012)
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Questions

  1. Our CDMO has used 45% Glucose for manufacture. The supplier code they gave us is CR20057-1L and CR20057-50L. They do not have any other code filed. Can you confirm that CR20057 and G8769 are the same product and the same specification release applies?

    1 answer

    1. The product you are inquiring about, CR20057, is manufactured on a custom basis.

      For further information please contact your local or regional technical support team. We kindly ask you to navigate to the link https://www.sigmaaldrich.com/techservice, click on "Report Product Issues" under the Products Section with all the required information so that a member of our team can reach out to you to assist further. Thank you

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