F7680
FAK (393-698), active, His tagged human
PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
Synonym(s):
FADK, FAK1, PTK2, pp125FAK
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About This Item
UNSPSC Code:
12352204
NACRES:
NA.32
Pricing and availability is not currently available.
Recommended Products
recombinant
expressed in baculovirus infected Sf9 cells
Quality Level
product line
PRECISIO® Kinase
Assay
≥70% (SDS-PAGE)
form
buffered aqueous glycerol solution
specific activity
221-299 nmol/min·mg
mol wt
~35 kDa
UniProt accession no.
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... PTK2(5747)
General description
Focal adhesion kinase (FAK) or PTK2 (protein tyrosine kinase 2) is a tyrosine kinase, which resides in the cytoplasm, and concentrated at cellular focal points. It is a highly conserved 125kDa protein, which has a wide range of tissue expression. It is composed of 1,052 amino acids, and contains N- and C-termini flanking the central kinase domain. The N-terminal called the FERM (four-point-one, ezrin, radixin, moesin) domain, controls FAK activity, whereas the C-terminal contains the focal-adhesion-targeting (FAT) domain.[1]
Biochem/physiol Actions
Focal adhesion kinase (FAK) or PTK2 protein tyrosine kinase 2 plays multiple roles such as, control of transcription, cell cycle progression, apoptosis, cell migration, and metastasis in case of tumor cells. This attributes to its predominant role in cell signaling. It is involved in the infection of rabies virus (RABV).[1] Studies in Spanish population show that polymorphisms rs7460 and rs7843014 in this gene might be linked with exceptional longevity.[2] Phosphatidylinositol 4-phosphate 5-kinase type Iγ enzyme produces phosphatidylinositol-4,5-bisphosphate [PI(4,5)P2] in focal adhesion, which cross-links FAK activation to integrin signaling.[3]
Physical form
Supplied in 50mM NaPhosphate pH 7.0, 300 mM NaCl, 150 mM imidazole, 0.1mM PMSF, 0.2 mM DTT, 25% glycerol.
Legal Information
PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class Code
10 - Combustible liquids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Nuria Garatachea et al.
Rejuvenation research, 17(5), 430-438 (2014-06-17)
Focal adhesion is critical for cell survival. The focal adhesion kinase (FAK, or PTK2) is an important component of the human interactome and thus is a potential longevity-related protein. Here we studied the association between two PTK2 gene single-nucleotide polymorphisms
Guillermina M Goñi et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(31), E3177-E3186 (2014-07-23)
Focal adhesion kinase (FAK) is a nonreceptor tyrosine kinase (NRTK) with key roles in integrating growth and cell matrix adhesion signals, and FAK is a major driver of invasion and metastasis in cancer. Cell adhesion via integrin receptors is well
Veronica Gabarra-Niecko et al.
Cancer metastasis reviews, 22(4), 359-374 (2003-07-30)
Since its initial discovery as a substrate and binding partner for the Src oncogene, a role for the focal adhesion kinase (FAK) in cancer has been speculated. In this review the clinical evidence correlating FAK overexpression with cancer and the
M D Schaller
Biochimica et biophysica acta, 1540(1), 1-21 (2001-07-31)
The focal adhesion kinase, FAK, is an important component of an integrin-dependent signaling pathway, which functions to transmit signals from the extracellular matrix into the cytoplasm. FAK is an essential gene product, since the fak-/- mouse exhibits embryonic lethality. A
Baptiste Fouquet et al.
Journal of virology, 89(3), 1640-1651 (2014-11-21)
The rabies virus (RABV) phosphoprotein P is a multifunctional protein: it plays an essential role in viral transcription and replication, and in addition, RABV P has been identified as an interferon antagonist. Here, a yeast two-hybrid screen revealed that RABV
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