E7277
Elastin, soluble from human lung
lyophilized powder
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About This Item
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biological source
human lung
Quality Level
form
lyophilized powder
impurities
salt, free
solubility
H2O: >10 mg/mL (more soluble at pH>7)
UniProt accession no.
storage temp.
2-8°C
InChI
1S/C27H48N6O6/c1-9-17(6)23(32-24(36)19(13-15(2)3)30-18(7)34)26(38)29-14-21(35)31-22(16(4)5)27(39)33-12-10-11-20(33)25(37)28-8/h15-17,19-20,22-23H,9-14H2,1-8H3,(H,28,37)(H,29,38)(H,30,34)(H,31,35)(H,32,36)/t17-,19-,20-,22-,23-/m0/s1
InChI key
DPUYCSDGMSDKKV-MKBYFEBXSA-N
Gene Information
human ... ELN(2006)
Application
Elastin is a structural protein which has been used in studies of chronic obstructive pulmonary disease (COPD). It may be used to investigate why there is a lack of repair for these proteins in patients with COPD.
Preparation Note
Prepared from E7152 using the method of Partrige, et al.[1]
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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The chemistry of connective tissues. 2. Soluble proteins derived from partial hydrolysis of elastin.
S M PARTRIDGE et al.
The Biochemical journal, 61(1), 11-21 (1955-09-01)
Wei Li et al.
Arteriosclerosis, thrombosis, and vascular biology, 33(5), 1028-1035 (2013-03-16)
Patients with elastin deficiency attributable to gene mutation (supravalvular aortic stenosis) or chromosomal microdeletion (Williams syndrome) are characterized by obstructive arteriopathy resulting from excessive smooth muscle cell (SMC) proliferation, mural expansion, and inadequate vessel size. We investigated whether rapamycin, an
Jae-Yol Lim et al.
PloS one, 8(1), e54256-e54256 (2013-02-02)
Vocal fold (VF) scarring remains a therapeutic challenge. Granulocyte-macrophage colony-stimulating factor (GM-CSF) facilitates epithelial wound healing, and recently, growth factor therapy has been applied to promote tissue repair. This study was undertaken to investigate the effect of GM-CSF on VF
Wolfgang G Mouton et al.
Swiss medical weekly, 143, w13755-w13755 (2013-02-28)
The ultrastructure of venous valves and walls in chronic venous disease was investigated. Consecutive patients were categorised into one of three groups (group A: patients with C1 venous disease in accordance with CEAP (Clinical severity, Etiology, Anatomy, Pathophysiology); group B:
Andrew L Wishart et al.
Science advances, 6(43) (2020-10-23)
The extracellular matrix (ECM), a major component of the tumor microenvironment, promotes local invasion to drive metastasis. Here, we describe a method to study whole-tissue ECM effects from disease states associated with metastasis on tumor cell phenotypes and identify the
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