The following reference uses Dynasore at 80 μM: Massol, R.H., et al., A burst of auxilin recruitment determines the onset of clathrin-coated vesicle uncoating. Proc. Nat. Acad. Sci., USA, 103, 10265-10270 (2006).
D7693
Dynasore hydrate
≥97.5% (HPLC), powder, dynamin 1 and dynamin 2 GTPase activity inhibitor
Synonym(s):
3-Hydroxy-naphthalene-2-carboxylic acid (3,4-dihydroxy-benzylidene)-hydrazide hydrate
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About This Item
Empirical Formula (Hill Notation):
C18H14N2O4 · xH2O
CAS Number:
Molecular Weight:
322.31 (anhydrous basis)
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
Pricing and availability is not currently available.
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Product Name
Dynasore hydrate,
form
powder
Quality Level
storage condition
protect from light
color
off-white
solubility
DMSO: ≥10 mg/mL
H2O: insoluble
storage temp.
−20°C
SMILES string
O.Oc1ccc(\C=N\NC(=O)c2cc3ccccc3cc2O)cc1O
InChI
1S/C18H14N2O4.H2O/c21-15-6-5-11(7-17(15)23)10-19-20-18(24)14-8-12-3-1-2-4-13(12)9-16(14)22;/h1-10,21-23H,(H,20,24);1H2/b19-10+;
InChI key
FKWZHQSDBMSHTN-ZIOFAICLSA-N
General description
Dynasore is a small molecule GTPase inhibitor that targets dynamin-1, dynamin-2 and Drp1 (mitochondrial). Dynasore blocks dynamin-dependent endocytosis, scission of endocytic vesicles. Dynosore is profibrotic, induces PAI-1 in pleural mesothelial cells, and may be an effective pleurodesing (pleurodesis) agent. Dynasor blocks human papillomavirus type 16 (HPV16) and bovine papillomavirus type 1 (BPV1) (pseudovirions) infections.
Dynasore hydrate lowers labile cholesterol in the plasma membrane and distorts lipid raft organization.[1] Dynasore exhibits pleotropic effects on herpes simplex virus (HSV)-1 and HSV-2 infection. It hinders viral entry, trafficking of viral proteins and capsid formation.[2]
Dynasore hydrate lowers labile cholesterol in the plasma membrane and distorts lipid raft organization.[1] Dynasore exhibits pleotropic effects on herpes simplex virus (HSV)-1 and HSV-2 infection. It hinders viral entry, trafficking of viral proteins and capsid formation.[2]
Application
Dynasore hydrate has been used:
- for priming fetal mesenchymal stem/stromal cells (fMSC)[3]
- in confocal microscopy[4]
- in wound healing/scratch and tube-formation assay[5]
- to analyse its effects on Coxsackievirus A9 (CAV9) infection[6]
- to inhibit clathrin-mediated endocytosis and caveolin-mediated endocytosis[7]
- in live imaging of cells[8]
Biochem/physiol Actions
Dynasore is a cell-permeable, reversible noncompetitive dynamin 1 and dynamin 2 GTPase activity inhibitor.
Features and Benefits
This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Aquatic Acute 1
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Tom Kirchhausen et al.
Methods in enzymology, 438, 77-93 (2008-04-17)
The large GTPase dynamin is essential for clathrin-dependent coated-vesicle formation. Dynasore is a cell-permeable small molecule that inhibits the GTPase activity of dynamin1, dynamin2 and Drp1, the mitochondrial dynamin. Dynasore was discovered in a screen of approximately 16,000 compounds for
Dynasore-not just a dynamin inhibitor
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What concentration of Product D7693, Dynasore hydrate, should I use in my experiment?
1 answer-
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How can I store a solution of Product D7693, Dynasore hydrate?
1 answer-
We do not test solution stability for this product. In general, drug solutions are best prepared immediately before use. We recommend storing at -20°C in single use aliquots.
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What is the Department of Transportation shipping information for this product?
1 answer-
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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What can I use to make a solution of Product D7693, Dynasore hydrate?
1 answer-
As listed on the product page on the website, Dynasore is soluble in DMSO at 10 mg/mL. It is also soluble in ethanol at 1 mg/mL.
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