C2854

Caspase 2 human

≥95% (SDS-PAGE), recombinant, expressed in E. coli, buffered aqueous solution, >1000 units/mg protein

• Synonym(s): Ich-1, Nedd2
• MDL number: MFCD02686998
• UNSPSC Code: 12352200

Properties

• recombinant: expressed in E. coli
• Assay: ≥95% (SDS-PAGE)
• form: buffered aqueous solution
• specific activity: >1000 units/mg protein
• mol wt: inactive proenzyme 56 kDa (active form consists of 17 kDa and 10 kDa subunits); ≥30 kDa
• UniProt accession no.: P42575
• storage temp.: −20°C
• Gene Information: human ... CASP2(835)

Description

Biochem/physiol Actions

Caspase 2 plays a major role in both positive and negative regulation of programmed cell death. It exists as two spliced variants, Ich-1L (long) and Ich-1S (short). Functionally, the two forms differ in that overexpression of the long form will induce apoptosis, while overexpression of the short form suppresses cell death.

Caspase 2 plays a major role in both positive and negative regulation of programmed cell death; exists as two spliced variants, Ich-1L (long) and Ich-1S (short).

Unit Definition

One unit will hydrolyze one nmol of N-Acetyl-Val-Asp-Val-Ala-Asp-AFC per min at pH 7.5 at 25 °C.

Physical form

Solution in 25 mM HEPES, pH 7.5, 0.15 M NaCl, 5 mM dithiothreitol, 10% sucrose, with 0.5 mg bovine serum albumin

Safety Information

• Storage Class Code: 12 - Non Combustible Liquids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable