HoxD3 is a homeobox transcription factor that activates collagen synthesis and angiogenesis and can accelerate wound healing in mice. HOXD3 (HOX4A) has also been implicated in cell adhesion. Rabbit Anti-HOXD3 (AB1) antibody recognizes canine, human, mouse, rat, and bovine HOXD3.
Immunogen
Synthetic peptide directed towards the middle region of human HOXD3
Application
Rabbit Anti-HOXD3 (AB1) antibody can be used for immunohistochemical assays at a concentration of 4-8μg/ml, using paraffin-embedded tissues. The antibody can also be used for western blot assays 1-2μg/ml.
Biochem/physiol Actions
HOXD3 (homeobox D3) belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located at 2q31-2q37 chromosome regions. Deletions that remove the entire HOXD gene cluster or 5′ end of this cluster have been associated with severe limb and genital abnormalities. HOXD3 may play a role in the regulation of cell adhesion processes.
Sequence
Synthetic peptide located within the following region: AHKGAELNGSCMRPGTGNSQGGGGGSQPPGLNSEQQPPQPPPPPPTLPPS
Physical form
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
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Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
We previously isolated the human homeobox gene HOX4A (HOXD3) on chromosome 2 from a human genomic library and determined its nucleotide sequence. In the present study, expression of the HOX4A gene was investigated in human hematopoietic cell lines. Reverse transcriptase-mediated
The American journal of pathology, 163(6), 2421-2431 (2003-11-25)
Poorly healing diabetic wounds are characterized by diminished collagen production and impaired angiogenesis. HoxD3, a homeobox transcription factor that promotes angiogenesis and collagen synthesis, is up-regulated during normal wound repair whereas its expression is diminished in poorly healing wounds of
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