Skip to Content
Merck
All Photos(1)

Key Documents

A4056

Sigma-Aldrich

Amrinone

Synonym(s):

5-Amino-(3,4′-bipyridin)-6(1H)-one, Inamrinone

Sign Into View Organizational & Contract Pricing


About This Item

Empirical Formula (Hill Notation):
C10H9N3O
CAS Number:
Molecular Weight:
187.20
EC Number:
MDL number:
UNSPSC Code:
12352202
PubChem Substance ID:
Pricing and availability is not currently available.

Assay

≥98% (TLC)

Quality Level

form

powder

solubility

1 M NaOH: 100 mg/mL

storage temp.

2-8°C

SMILES string

NC1=CC(=CNC1=O)c2ccncc2

InChI

1S/C10H9N3O/c11-9-5-8(6-13-10(9)14)7-1-3-12-4-2-7/h1-6H,11H2,(H,13,14)

InChI key

RNLQIBCLLYYYFJ-UHFFFAOYSA-N

Gene Information

human ... PDE3A(5139)
rat ... Pde3a(50678)

Looking for similar products? Visit Product Comparison Guide

Biochem/physiol Actions

Simple, non-glycoside cardiotonic agent, possibly via its phosphodiesterase III (PDE-III) inhibitory action.[1]
Simple, non-glycoside cardiotonic agent, possibly via its phosphodiesterase III (PDE-III) inhibitory action.[1] Independent of its cardiac effects, amrinone provides protection against ischemia-reperfusion injury in kidney,[2] liver,[3] and heart.[4]

Pictograms

Skull and crossbones

Signal Word

Danger

Hazard Statements

Precautionary Statements

Hazard Classifications

Acute Tox. 3 Oral

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

A G Iavorovskiĭ et al.
Anesteziologiia i reanimatologiia, (5)(5), 5-10 (2006-12-23)
The paper deals with the development of a diagnostic and therapeutic algorithm of intraoperative heart failure during cardiosurgical operations on the basis of evaluation of systolic and diastolic functions of the left and right ventricles. The study included 101 patients
C Aydin et al.
European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes, 42(3), 189-194 (2009-02-28)
Common bile duct ligation (CBDL) in the guinea pig is a well-defined model of acalculous cholecystitis. Nitric oxide (NO) mediates smooth muscle relaxation by stimulating the activity of soluble guanylate cyclase. The aim of this study was to determine whether
Nuria Albet-Torres et al.
The Journal of biological chemistry, 284(34), 22926-22937 (2009-06-13)
Amrinone is a bipyridine compound with characteristic effects on the force-velocity relationship of fast skeletal muscle, including a reduction in the maximum shortening velocity and increased maximum isometric force. Here we performed experiments to elucidate the molecular mechanisms for these
Su-Gang Gong et al.
Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics, 9(3), 233-236 (2007-06-22)
To investigate the protective effect of amrinone against experimental lung ischemia /reperfusion (I/R) injury. Twenty-four Sprague-Dawley rats were randomly divided into 3 groups (n=8 each): sham- operated group, I/R group, and amrinone-treated I/R group (AMR group). The left lung of
Thiranat Tanwiphongtrakun et al.
Acta anaesthesiologica Taiwanica : official journal of the Taiwan Society of Anesthesiologists, 44(3), 183-185 (2006-10-14)
We came across a case who because of sustained hypotension with normal cardiac output was given amrinone which offered an initial excellent response but showed impotency later and its replacement by milrinone dramatically improved the hemodynamic status. The ensuing hypotension

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service