This product has not been tested for in vivo or in vitro applications. Suitability for in vitro use will need to be validated by the end-user. The material is purified from Escherichia coli and has not tested for endotoxin. Solutions would require sterile filtration prior to adding to cultures. Alternatively, product 110138 is a synthetically produced product option. While not tested for in vitro use, it may be a better option for sensitive cell lines. It is not sterile and solutions would also required filter sterilization. See the link below to review this product:
https://www.sigmaaldrich.com/product/mm/110138
A2388
N-Acetylneuraminic acid
≥98% (HPLC), from Escherichia coli
Synonym(s):
5-Acetamido-3,5-dideoxy-D-glycero-D-galactononulosonic acid, Lactaminic acid, NAN, NANA, Sialic acid
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All Photos(5)
About This Item
Empirical Formula (Hill Notation):
C11H19NO9
CAS Number:
Molecular Weight:
309.27
Beilstein:
1716283
EC Number:
MDL number:
UNSPSC Code:
12352201
PubChem Substance ID:
NACRES:
NA.25
Pricing and availability is not currently available.
Recommended Products
biological source
Escherichia coli
Quality Level
type
Type VI
Assay
≥98% (HPLC)
form
powder
optical activity
[α]20/D -34.0 to -30.0 °, c = 1% in water
technique(s)
HPLC: suitable
color
white to off-white
mp
184-186 °C
solubility
water: 50 mg/mL, clear, colorless
storage temp.
−20°C
SMILES string
O[C@@]1(O[C@@]([C@@H]([C@H](C1)O)NC(C)=O)([H])[C@@H]([C@@H](CO)O)O)C(O)=O
InChI
1S/C11H19NO9/c1-4(14)12-7-5(15)2-11(20,10(18)19)21-9(7)8(17)6(16)3-13/h5-9,13,15-17,20H,2-3H2,1H3,(H,12,14)(H,18,19)/t5-,6+,7+,8+,9+,11-/m0/s1
InChI key
SQVRNKJHWKZAKO-PFQGKNLYSA-N
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Application
N-Acetylneuraminic acid (NANA, Neu5Ac) is a major component of glycoconjugates such as glycolipids, glycoproteins and proteoglycans (sialogylcoproteins) where it confers selective binding characteristics to the glycosylated component. Neu5Ac is used to study its biochemistry, metabolism and uptake in vivo and in vitro. Neu5Ac is used in the development of nanocarriers.
Biochem/physiol Actions
Both sialic acid and neuraminic acid are loosely used to refer to conjugates of neuraminic acid. N-Acetylneuraminic acid is often found as the terminal sugar of cell surface glycoproteins. Cell surface glycoproteins have important roles in cell recognition and interaction as well as in cell adhesion. Membrane glycoproteins are also important in tumor growth and metastases.
Other Notes
To gain a comprehensive understanding of our extensive range of Monosaccharides for your research, we encourage you to visit our Carbohydrates Category page.
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Eye Irrit. 2
Storage Class Code
11 - Combustible Solids
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Protocols
Enzymatic Assay of Neuraminidase applies to products that have a specification for neuraminidase content by enzymatic determination.
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I was wondering if the Sigma-Aldrich (A2388) N-Acetylneuraminic acid from Escherichia coli, ≥98%, is suitable to use in vitro on oligodendrocytes. In other words, is it sterile? Thank you in advance.
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