Skip to Content
Merck
All Photos(1)

Documents

89282

Sigma-Aldrich

Thymidine 5′-diphosphate sodium salt

≥90% (HPLC)

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Empirical Formula (Hill Notation):
C10H16N2O11P2 · xNa+
CAS Number:
108322-12-9
Molecular Weight:
402.19 (free acid basis)
EC Number:
306-019-3
MDL number:
MFCD00084748
UNSPSC Code:
41106305
PubChem Substance ID:
57653338

biological source

animal
plant

Assay

≥90% (HPLC)

form

powder

solubility

water: 50 mg/mL, clear, colorless

shipped in

wet ice

storage temp.

−20°C

SMILES string

[Na+].[Na+].[Na+].CC1=CN([C@H]2C[C@H](O)[C@@H](COP([O-])(=O)OP([O-])([O-])=O)O2)C(=O)NC1=O

InChI

1S/C10H16N2O11P2.3Na/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(22-8)4-21-25(19,20)23-24(16,17)18;;;/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,11,14,15)(H2,16,17,18);;;/q;3*+1/p-3/t6-,7+,8+;;;/m0.../s1

InChI key

HBYPEEZBYHQLDM-SPSULGLQSA-K

Looking for similar products? Visit Product Comparison Guide

Application

Thymidine ′-diphosphate (dTDP) may be used to study the distribution and kinetics of various nucleoside diphosphate kinases and dTDP specific nucleoside diphosphate kinases.

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Chia-Yi Chien et al.
FEBS letters, 583(13), 2281-2286 (2009-06-23)
The existence of multifunctional enzymes in the nucleotide biosynthesis pathways is believed to be one of the important mechanisms to facilitate the synthesis and the efficient supply of deoxyribonucleotides for DNA replication. Here, we used the bacterially expressed yeast thymidylate
S Schaertl et al.
The Journal of biological chemistry, 274(29), 20159-20164 (1999-07-10)
The Ser122 --> Pro mutation in human nucleoside diphosphate kinase (NDK)-B/Nm23-H2 was recently found in melanoma cells. In comparison to the wild-type enzyme, steady state activity of NDKS122P with ATP and TDP as substrates was slowed down 5-fold. We have
A Yano et al.
Plant molecular biology, 27(5), 1053-1058 (1995-03-01)
The GST (glutathione S-transferase)-NDK (nucleoside diphosphate kinase) fusion protein was expressed in Escherichia coli. The GST-NDK protein was capable of transferring gamma-phosphate from ATP to nucleoside diphosphates such as GDP, CDP, TDP and UDP. Western blot analysis using anti-NDK antibody
P Gonin et al.
Biochemistry, 38(22), 7265-7272 (1999-06-03)
Nucleoside diphosphate (NDP) kinases display low specificity with respect to the base moiety of the nucleotides and to the 2'-position of the ribose, but the 3'-hydroxyl is found to be important for catalysis. We report in this paper the enzymatic

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service